| Dance Central | Harmonix Music Systems, Q389261 | 3 | music video game |
| Dance Dance Revolution | Konami | 64 | music video game |
| Dancing Stage | Konami | 1 | music video game |
| Dark Parables | — | 1 | adventure video game |
| Dark Seal | — | 2 | action role-playing game, beat 'em up |
| Darksiders | — | 5 | post-apocalyptic video game |
| Darkstalkers | Capcom, Iron Galaxy Studios | 9 | 2D fighting game |
| Daymare | Invader Studios | 2 | survival horror, action-adventure game |
| DC Super Hero Girls | — | 2 | comedy drama |
| Dead or Alive | Tomonobu Itagaki, Team Ninja | 23 | fighting game |
| Dead Space | Visceral Games | 6 | survival horror, third-person shooter |
| Dead to Rights | — | 5 | third-person shooter |
| Deadtime Stories | — | — | puzzle video game |
| DearS | — | 1 | ecchi, science fiction anime and manga, harem |
| DecAthlete | — | 2 | sports video game |
| Deep Dungeon | HummingBirdSoft | 4 | role-playing video game |
| Deer Hunter | Glu Mobile, Sunstorm Interactive | 2 | first-person shooter, hunting video game |
| Deluxe Ski Jump | — | 4 | ski jumping video game |
| Dementium | Renegade Kid | 2 | first-person shooter, survival horror |
| Demon Slayer: Kimetsu no Yaiba | — | 1 | — |
| Densha de Go! | Taito | 5 | train simulator |
| Descent | — | 3 | first-person shooter |
| Detective Grimoire series | SFB Games | 3 | detective video game |
| Devil Summoner Series | Q780528 | 6 | role-playing video game |
| Diablo | Blizzard Entertainment | 9 | dungeon crawl, action role-playing game |
| Diabolik Lovers | Rejet | 7 | otome game, visual novel, dark fantasy |
| Digimon | Akiyoshi Hongo | 1 | — |
| Dino Crisis | Capcom | 5 | survival horror |
| Dino Hazard | — | 1 | — |
| Disaster Report | Granzella, Irem | 5 | survival game, action-adventure game |
| Disciples | Strategy First | 11 | fantasy video game |
| Disgaea | — | 14 | tactical role-playing game |
| Disney Infinity | Avalanche Software | 1 | crossover fiction |
| Disney Sports | Konami | 6 | — |
| Disney's Animated Storybook | — | 10 | — |
| Disney's Magical Quest | Capcom | 3 | platform game |
| Dizzy | Oliver Twins | 12 | adventure video game, puzzle video game, platform game |
| Djibril – The Devil Angel | Front Wing | — | eroge, hentai, visual novel, magical girl anime and manga |
| DJMax | Pentavision, Neowiz | 1 | rhythm game, music video game |
| Doctor Who: The Adventure Games | Sumo Digital | 5 | adventure video game |
| Dokapon | — | 7 | role-playing video game, party video game |
| Don't Escape | Scriptwelder Studio | 6 | — |
| Double Breakout | nuGAME | 1 | Breakout clone |
| Double Dragon | — | 12 | beat 'em up |
| Dracula Series | — | 1 | adventure video game |
| Dragon Ball Z: Budokai Tenkaichi | — | 4 | fighting game |
| Dragon Quest | Heartbeat, Level-5, Chunsoft | 38 | fantasy anime and manga, Japanese role-playing video game, role-playing video game |
| Dragon's Lair | — | 1 | fantasy video game |
| Drakan | — | 2 | action-adventure game |
| Drakengard | — | 8 | action role-playing game |
| Drawn | Big Fish Games | — | puzzle video game |
| Dune | — | 4 | real-time strategy |
| Dungeon Defenders | Chromatic Games | 5 | — |
| Dynasty Tactics | — | 2 | turn-based strategy video game |
| Dynasty Warriors | — | 37 | hack and slash |
| Dōsōkai | — | 4 | eroge, visual novel |