| Macross | Studio Nue, Artland, Shōji Kawamori | 2 | — |
| Madagascar | — | 2 | — |
| Madō Monogatari | — | 3 | role-playing video game |
| Mafia | Q222045, Q5647891 | 8 | action-adventure game, third-person shooter |
| Magic-kyun Renaissance | — | 1 | — |
| Majin Tensei | — | 4 | tactical role-playing game |
| Make My Video | Digital Pictures | — | — |
| Mana | Square Enix, Square | 12 | action role-playing game |
| Manchester United | — | 1 | association football video game |
| Manhunt | Rockstar London, Rockstar Vienna | 1 | psychological horror fiction, stealth game |
| Mario | Shigeru Miyamoto, Nintendo | 16 | educational video game, adventure video game, puzzle video game, role-playing video game, party video game, platform game, racing video game, sports video game |
| Mario Artist | Nintendo Entertainment Analysis & Development | 4 | — |
| Medal of Honor | Rebellion Developments, 2015, Inc., Danger Close Games, DICE, EA Vancouver | 15 | first-person shooter |
| MediEvil | Guerrilla Cambridge | 4 | hack and slash, action-adventure game |
| Mega Man | Capcom | 23 | action game, platform game |
| Mega Man Battle Network | Capcom | 16 | role-playing video game |
| Mega Man Legends | — | 4 | action game, science fiction video game |
| Mega Man X | — | 15 | action game, science fiction video game |
| Mega Man Zero | Inti Creates | 6 | action game |
| Melty Blood | — | 3 | visual novel, fighting game |
| Memories Off After Rain | — | — | drama anime and manga, visual novel |
| Memory Clip | Empty Clip Studios, City Connection | — | — |
| Men of War | Digitalmindsoft, Best Way, Softclub | 12 | real-time tactics |
| Mercenaries | — | 2 | action-adventure game |
| Metal Gear | Silicon Knights, Q1576758, Konami | 25 | cyberpunk video game, stealth game |
| Metal Slug | SNK | 17 | shoot 'em up |
| Mia's Big Adventure Collection | Kutoka Interactive | 4 | — |
| Micro Machines | Codemasters, Supersonic Software | 1 | racing video game |
| Microsoft Combat Flight Simulator | Xbox Game Studios | 3 | combat flight simulator game |
| Midnight Club | Q959329 | 4 | arcade, racing video game |
| Midtown Madness | Q959329 | 3 | racing video game |
| Midway Arcade Treasures | Midway Games, Q389261, Midway Studios San Diego | 6 | — |
| Milk Junkies | — | — | eroge |
| Minecraft | — | 1 | sandbox game |
| MLB: The Show | — | 19 | sports video game |
| Modern Combat | Gameloft | 8 | first-person shooter |
| Moegaku | — | — | magical girl anime and manga |
| Momotarō Densetsu | — | 4 | role-playing video game |
| Monica and Friends | — | 2 | — |
| Monster Box | YSO Corp | 2 | monster-taming game |
| Monster Energy Supercross: The Official Videogame | Milestone S.r.l. | 6 | supercross racing video game |
| Monster Girl Quest | — | 3 | eroge, fantasy video game, episodic video game, visual novel, harem |
| Monster Rancher | — | 13 | role-playing video game |
| Mortal Kombat | Midway Games, NetherRealm Studios | 26 | fighting game |
| Motocross Madness | — | 3 | vehicle simulation game, racing video game |
| MotoGP | Milestone S.r.l. | 18 | racing video game |
| MotorStorm | — | 5 | racing video game |
| Mount & Blade | TaleWorlds | 4 | — |
| Munchers | — | 2 | — |
| Muv-Luv | — | 6 | — |
| MXGP | Milestone S.r.l. | 8 | motocross racing video game |
| My Little Pony | Hasbro | 2 | — |
| My Time | Pathea Games | 3 | — |
| MySims | Hudson Soft, Visceral Games, Q2080076, Tose Co., Babaroga | 7 | life simulation game |
| Mystery Case Files | GrandMA Studios | 32 | casual game, adventure video game, hidden object game |
| Myth | — | 3 | real-time tactics |