| Series | Created by | Games | Genre |
|---|---|---|---|
| UEFA Euro | — | 5 | association football video game |
| UFO | Altar Games | 1 | — |
| Ultima | Origin Systems | 17 | role-playing video game |
| Ultima Underworld | Looking Glass Studios | 2 | role-playing video game |
| Ultimate Soccer Manager | — | 1 | association football video game |
| Ultra Series | Eiji Tsuburaya | 2 | — |
| Uma Musume Pretty Derby | Cygames | 2 | spokon |
| Umineko When They Cry | — | 6 | — |
| Uncle Albert's adventures | Éric Viennot | — | adventure video game |
| Under Night In-Birth | French-Bread | 5 | 2D fighting game |