| E-hon series | Nippon Ichi Software | 2 | — |
| EA Sports UFC | — | 4 | sports video game |
| Earth and Sky | — | — | interactive fiction |
| Earth Defense Force | — | 12 | third-person shooter |
| Earthworm Jim | VIS Entertainment, Eurocom, Shiny Entertainment, Gameloft | 7 | platform game |
| EcoQuest | — | 2 | — |
| Elemental War | Clockwork Origins | 2 | tower defense |
| Elementibox | — | — | music video game |
| Elite | — | 3 | space flight simulation game |
| Emerald Mine | — | 3 | rocks-and-diamonds video game |
| Empire of Angels | Softstar Entertainment | — | turn-based strategy video game |
| Empire Earth | Rockstar New England, Stainless Steel Studios | 7 | real-time strategy |
| Escape Velocity | Ambrosia Software | — | space opera video game, space trading and combat game, role-playing video game |
| Etrian Odyssey | Q780528 | 11 | Japanese role-playing video game, role-playing video game |
| Europa Universalis | — | 6 | 4X |
| Everybody's Golf | — | 10 | golf video game, sports video game |
| EyePet | London Studio | 2 | — |