| Saber Marionette | — | 1 | — |
| Sakura Wars | Oji Hiroi, Q122741, Red Entertainment | 7 | dating sim, action role-playing game, tactical role-playing game, harem |
| Samorost | Jakub Dvorský, Amanita Design | 3 | graphic adventure game, art game |
| Samurai Shodown | SNK | 5 | 2D fighting game, 3D fighting game |
| Sargon | — | 1 | chess video game |
| Saturn Tribute | City Connection | 8 | — |
| SBK | Milestone S.r.l. | 7 | racing video game |
| Scene It? | — | 5 | trivia video game, party video game |
| Science Adventure | — | 8 | science fiction video game, visual novel |
| Scoob! | — | 1 | mystery film, comedy film |
| Scratch Fusion | Jacob the Orange Yoshi | — | boss game, platform game |
| Scribblenauts | — | 6 | puzzle video game |
| SD Gundam G Generation | — | 2 | mecha video game |
| Secret Files | — | 5 | adventure video game |
| Sega 3D Reprint Archives | M2 | 3 | — |
| Sega Superstars | Sonic Team, Sumo Digital | 4 | crossover fiction |
| Sega Worldwide Soccer | — | 2 | association football video game |
| Sentinel Girls | — | 2 | shoot 'em up, tower defense, side-scrolling video game, dystopian fiction, shooter game |
| Serious Sam | Croteam | 34 | first-person shooter |
| Sexy Poker | — | 1 | strip poker video game |
| Seymour | Big Red Software | 1 | platform game |
| Shadow Hearts | SNK, Sacnoth | 4 | role-playing video game |
| Shadow Warrior | — | 2 | first-person shooter |
| Shadowgrounds | — | 3 | shoot 'em up |
| Shadowrun | — | 3 | science fantasy video game |
| Shaman King | — | 8 | — |
| Shantae | Matt Bozon, WayForward Technologies | 6 | action-adventure game, platform game |
| Shenmue | — | 4 | action-adventure game |
| Shin Megami Tensei: Devil Children | — | 4 | tactical role-playing game, puzzle video game, role-playing video game |
| Shining | Camelot Software Planning | 20 | role-playing video game |
| Shovel Knight | — | 2 | puzzle video game, platform game, fighting game |
| Silent Hill | Keiichiro Toyama, Vatra Games, Double Helix Games, WayForward Technologies, Climax Studios, Creature Labs | 13 | survival horror |
| Silfade series | — | — | adventure video game, role-playing video game |
| Silver Falls | Sungrand Studios | 2 | survival horror, third-person shooter |
| SimCity | Maxis | 21 | construction and management simulation, strategy, city-building game |
| Simple | — | 3 | — |
| Simple DS Series | INTENSE | 4 | adventure video game |
| Simple Wii Series | INTENSE | — | adventure video game |
| SingStar | London Studio | 10 | music video game, party video game |
| Siren | Japan Studio | 3 | psychological horror fiction |
| Sister Princess | — | 1 | comedy anime and manga |
| Ski Jump International | — | 3 | ski jumping video game |
| Ski Jumping | Metropolis Software, L’Art | 3 | ski jumping video game |
| Skullgirls | Hidden Variable Studios, M2, Lab Zero Games | 2 | 2D fighting game |
| Sky Gamblers | — | 1 | — |
| Skylanders | — | 5 | action-adventure game |
| Slave Maker | — | 3 | eroge, parody video game |
| Slender | — | 5 | psychological horror fiction |
| Slime | — | 3 | action-adventure game |
| Sly Cooper | Sanzaru Games, PlayStation Mobile, Inc. | 6 | platform game, stealth game |
| SNK vs. Capcom | — | 1 | crossover fiction |
| Snooper Troops | — | 1 | adventure video game |
| SOCOM U.S. Navy SEALs | — | 10 | third-person shooter |
| Sodium | — | 1 | massively multiplayer online game |
| Soldier of Fortune | — | 3 | first-person shooter |
| Sonic Blast Man | — | 2 | beat 'em up |
| Sonic the Hedgehog | Hudson Soft, Sonic Team, Sanzaru Games, Bioware, Sega Sports R&D, Traveller's Tales, Sumo Digital, Jupiter, Appaloosa Interactive, Sega AM2, SIMS Co., Ltd. +4 | 56 | — |
| Sorority Sex Kittens | — | 1 | pornographic film |
| Soul Eater | — | 3 | — |
| Soulcalibur | — | 10 | 3D fighting game |
| South Scrimshaw | — | 2 | speculative evolution, science fiction video game, mockumentary, visual novel |
| Space (series) | Edu-Ware | — | science fiction video game, role-playing video game |
| Space Channel 5 | — | 3 | music video game |
| Space Empires | — | 4 | space opera video game |
| Space Impact | — | 1 | shoot 'em up |
| Space Invaders | — | 5 | shoot 'em up |
| Space Marshals | Pixelbite | 3 | — |
| Space Quest | Q494614 | 7 | space opera video game, adventure video game |
| Space Rangers | — | 7 | — |
| Spec Ops | — | 7 | — |
| Spectrobes | Genki, Jupiter | 3 | action role-playing game, science fiction video game |
| Spice and Wolf | — | 2 | — |
| Spider-Man | Insomniac Games, Marvel Games | 3 | — |
| Spirit | — | 1 | animated film, adventure film, adventure television series |
| Splatoon | — | 5 | post-apocalyptic video game, third-person shooter |
| Splatterhouse | — | 5 | hack and slash, survival horror, beat 'em up |
| Star Fox | Q-Games, Q1576758, Nintendo Entertainment Analysis & Development, Nintendo Entertainment Planning & Development, Argonaut Games, Namco, Rare Ltd. | 9 | shoot 'em up, action-adventure game |
| Star Ocean | Tri-Ace | 9 | space opera video game, action role-playing game, Japanese role-playing video game |
| Star Soldier | Hudson Soft | 6 | shoot 'em up |
| Star Wars: Battlefront | — | 5 | space opera video game, first-person shooter, third-person shooter |
| Star Wars: Knights of the Old Republic | — | 11 | space opera video game, action role-playing game |
| Star Wars: Rogue Squadron | Lucasfilm Games, Factor 5 | 3 | action game |
| Star Wars: X-Wing | Totally Games | 16 | space combat simulation game |
| StarCraft | Blizzard Entertainment | 6 | real-time strategy |
| StarCraft II | Blizzard Entertainment | 1 | real-time strategy, military science fiction |
| Starstrike | — | 2 | shooter game |
| State of War (Game Series) | Cypronia | 3 | real-time strategy, science fiction video game |
| Steak and Jake | Flipline Studios | 2 | — |
| Steel Battalion | — | 3 | mech simulation game |
| Stickman Soccer | — | — | association football video game |
| Stoked Rider | — | 1 | snowboarding video game |
| Stories of Submission | Zee Vital, Marco Marco, Swimming Rock | 2 | erotic video game, visual novel |
| Story of Eroolia | Roseverte | 1 | otome game, visual novel |
| Story of Seasons | — | 29 | farming simulation game, business simulation game, life simulation game, Japanese role-playing video game |
| Strategic Command | — | 1 | turn-based strategy video game |
| Strawberry Panic! | — | 1 | — |
| Strider | Capcom | 5 | — |
| Strike | Electronic Arts | 5 | shoot 'em up |
| Strong Bad's Cool Game for Attractive People | Telltale Games | 5 | graphic adventure game |
| Stronghold | Firefly Studios | 7 | simulation video game, real-time strategy |
| Submachine | Mateusz Skutnik | — | point-and-click adventure |
| Sucker for Love | — | 3 | romance video game |
| Suikoden | — | 6 | role-playing video game |
| Super Real Mahjong | SETA Corporation | 7 | mahjong video game |
| Super Robot Wars | — | 24 | tactical role-playing game, crossover fiction |
| Super Sidekicks | SNK | 3 | association football video game |
| Super Smash Bros. | — | 5 | platform fighter, crossover fiction, action game, fighting game |
| Super Smash Flash | — | 2 | fighting game |
| Sveriges Radio's Christmas Calendar games | — | 1 | — |
| SVT's Christmas Calendar games | — | 21 | — |
| SWAT | — | 9 | tactical shooter |
| Swedish Erotica | Q3331758 | 3 | erotic video game |
| Syndicate | — | 4 | real-time tactics, cyberpunk video game |
| Synduality | Bandai Namco Holdings | 1 | — |
| Syphon Filter | Bend Studio | 7 | action-adventure game, third-person shooter |
| System Shock | Looking Glass Studios, Nightdive Studios, Irrational Games | 1 | first-person shooter |