| S.P.L.I.C.E.D. | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| S.T.A.L.K.E.R. 2: Heart of Chornobyl | first-person shooter, action game, science fiction video game, survival horror, role-playing video game | GSC Game World | Microsoft Windows, Xbox Series X and Series S |
| S.T.A.L.K.E.R.: Call of Pripyat | post-apocalyptic video game, first-person shooter, science fiction video game, survival horror | GSC Game World | Microsoft Windows |
| S.T.A.L.K.E.R.: Legends of the Zone Trilogy | first-person shooter | GSC Game World | — |
| Sabae no Ō | eroge, visual novel | — | Microsoft Windows |
| Sabre Team | — | Krisalis Software | Microsoft Windows, DOS, Atari ST, Amiga CD32 |
| Sacred | action role-playing game | Ascaron | Microsoft Windows, Linux |
| Sacred Cubes 2 | casual game, adventure video game | — | Microsoft Windows |
| Sacred Sword Princesses | role-playing video game | — | Microsoft Windows |
| Sacred Valley | — | Morning Shift Studios | Microsoft Windows |
| SacriFire | role-playing video game | Pixelated Milk | Microsoft Windows, Xbox Series X and Series S |
| Saikyō Saisoku Battle Racer | collectible card arcade game | Q122741 | arcade video game machine |
| Sail Ships | — | — | Microsoft Windows |
| Saint Emiliana | Japanese role-playing video game | — | Microsoft Windows |
| Saint Seiya : Ougon Densetsu | action role-playing game | Tose Co. | Nintendo Entertainment System |
| Saint Seiya Senki | action-adventure game | Dimps | PlayStation 3 |
| Saint Seiya: Brave Soldiers | fighting game | Dimps | PlayStation 3 |
| Saint Seiya: The Hades | fighting game | Dimps | — |
| Saints Row | action-adventure game | Mnemonic Studios | Java Platform, Micro Edition |
| Saints Row: Gold Edition | — | Q1458317 | Microsoft Windows, Xbox Series X and Series S |
| Saints Row: Platinum Edition | — | Q1458317 | Microsoft Windows, Xbox Series X and Series S |
| Sakura Angels | visual novel | Winged Cloud | Microsoft Windows, macOS, Linux |
| Sakura Beach | visual novel | Winged Cloud | Microsoft Windows, Linux |
| Sakura Fox Adventure | visual novel | Winged Cloud | Microsoft Windows, macOS, Linux |
| Sakura Gamer 2 | visual novel | Winged Cloud | Microsoft Windows, macOS, Linux |
| Sakura MMO Extra | simulation video game | Winged Cloud | Microsoft Windows, Linux |
| Sakura no Kumo * Scarlet no Koi | eroge, visual novel | Cabbage Soft | — |
| Sakura Sadist | visual novel | Winged Cloud | Microsoft Windows, macOS, Linux |
| Sakura Succubus 7 | simulation video game | — | Microsoft Windows, macOS, Linux |
| Sakura Succubus II | visual novel | Winged Cloud | Microsoft Windows, macOS, Linux, Mac |
| Sakura Taisen Online | minigame collection | Q122741 | — |
| Sakura Tale: The Tale of Cherry Blossoms Septet | — | — | Microsoft Windows |
| Sakura Wars 4: Fall in Love, Maidens | dating sim, tactical role-playing game | Red Entertainment | — |
| Sam & Max Beyond Time and Space | Christmas video game, graphic adventure game | Telltale Games | PlayStation 3, Microsoft Windows, macOS, Wii |
| Sam & Max: Culture Shock | adventure video game | Telltale Games | Microsoft Windows |
| Sam & Max: Night of the Raving Dead | adventure video game | Telltale Games | Microsoft Windows |
| Samantha Swift and the Golden Touch | hidden object game | MumboJumbo | Microsoft Windows |
| Samba de Amigo: Party Central | rhythm game | — | — |
| SAMOLIOTIK | — | Volens Nolens Games | Microsoft Windows |
| Samurai Aces | vertically scrolling shooter | City Connection, Zerodiv, Psikyo | Microsoft Windows, arcade video game machine, Android, Xbox Series X and Series S |
| Samurai Deeper Kyo | — | — | — |
| Samurai Jack: The Amulet of Time | — | — | — |
| Samurai of Hyuga | adventure video game, role-playing video game | Hosted Games | Microsoft Windows, macOS, Linux |
| Samurai of Hyuga Book 4 | adventure video game, role-playing video game | Hosted Games | Microsoft Windows, macOS, Linux |
| Samurai Shodown | fighting game | SNK | Neo Geo, Microsoft Windows, Super Nintendo Entertainment System, Game Boy, 3DO |
| Samurai Shodown | fighting game | SNK, Safari Games | Microsoft Windows, arcade video game machine, Xbox Series X and Series S |
| Samurai Shodown II | fighting game | SNK | Neo Geo, Microsoft Windows, Neo Geo CD, Android |
| Samurai Shodown NeoGeo Collection | fighting game | — | Microsoft Windows |
| Samurai Sword | — | — | Famicom Disk System |
| Samurai Warriors 4 | crowd-combat video game, hack and slash | Koei Tecmo Holdings | PlayStation 3, Microsoft Windows, PlayStation Vita |
| Samurai Warriors 5 | crowd-combat video game, hack and slash | Omega Force | Microsoft Windows |
| San Francisco Rush 2049 | racing video game | Atari Games, Handheld Games | Microsoft Windows, Nintendo GameCube, Nintendo 64, arcade video game machine, Game Boy Color |
| San Matias -- Mafia City | — | — | Microsoft Windows |
| Sanae Toumaden X | action game | — | Microsoft Windows |
| Sanatorium «Anthropocene Retreat» | casual game, adventure video game, action game, action-adventure game, role-playing video game | — | Microsoft Windows, macOS |
| Sanfu | suspense film, adventure video game, puzzle video game, role-playing video game | — | Microsoft Windows |
| Sangokushi Battlefield | real-time strategy | Koei | Microsoft Windows |
| Sanma no Meitantei | — | Namco | Nintendo Entertainment System |
| Sanrio Characters Picross | nonogram video game | Jupiter | Nintendo 3DS |
| Santa's vacation | — | — | Microsoft Windows, macOS |
| Sanvein | — | Success | — |
| SAOMI | adventure video game, action game, action-adventure game | Naoka Games | Microsoft Windows, Xbox Series X and Series S |
| Sargon V: World Class Chess | chess video game | — | Classic Mac OS |
| Satomi no Nazo | — | — | — |
| Saturday of Piercing Screams | casual game, action game | — | Microsoft Windows, macOS, Linux |
| Savage Pond | — | — | Acorn Electron, Commodore 64 |
| Save Daddy Trump | casual game, adventure video game | — | Microsoft Windows |
| Save Room | inventory management video game, puzzle video game | Fractal Projects | Microsoft Windows, Linux, Xbox Series X and Series S |
| Save The Heart Planet | adventure video game, role-playing video game | — | Microsoft Windows |
| Save the Ninja Clan | adventure video game, action game, action-adventure game | — | Microsoft Windows, macOS, Linux |
| Save the Reactor | simulation video game | — | Microsoft Windows, Linux |
| Saving You From Yourself | — | — | Microsoft Windows |
| Saviour of Humanity | — | — | Microsoft Windows |
| Savoir-Faire | — | — | — |
| Say No! More | comedy video game | Studio Fizbin | Microsoft Windows, macOS |
| Sayonara O Oshiete | visual novel | — | Microsoft Windows, Android |
| SBK-09: Superbike World Championship | racing video game | Milestone S.r.l. | PlayStation 3, Microsoft Windows |
| Scalak | puzzle video game | Hamster On Coke Games | Microsoft Windows, macOS, Linux |
| Scapegoat | casual game, action game | — | Microsoft Windows, macOS |
| Scarabaeus | — | Andromeda Software | Commodore 64 |
| Scary Hospital Horror Game | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Scary Wife HD: Anime Horror Game | casual game, simulation video game, adventure video game, action game, action-adventure game | — | Microsoft Windows, macOS, Linux |
| Scavenger SV-4 | — | — | Microsoft Windows |
| Scavenger's Deep | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Scene It? Lights, Camera, Action | game show | Q7135322 | — |
| Scene It? Twilight | trivia video game, party video game | Q7135322 | Wii |
| Schizofrenia | — | — | ZX Spectrum, Commodore 64 |
| Schizoids | action game | — | Microsoft Windows |
| School Bus Driver Simulator | casual game, simulation video game, racing video game | — | Microsoft Windows |
| School Days | eroge, romance video game | — | Microsoft Windows, DVD Player |
| School Girl/Zombie Hunter | third-person shooter | Tamsoft | Microsoft Windows |
| School Project ☆ | eroge, visual novel | Atelier Kaguya | Microsoft Windows |
| School Simulator RPG | simulation video game, adventure video game, action game, action-adventure game, role-playing video game | — | Microsoft Windows, macOS, Linux |
| School Sweets Discovery ～granulated sugar edition～ | casual game, adventure video game | — | Microsoft Windows |
| Schoolmate 2 | eroge | Illusion | — |
| Schwarzerblitz | fighting game | — | Microsoft Windows |
| Scooby-Doo | — | Gargoyle Games | ZX Spectrum, Amstrad CPC |
| Scooby-Doo and Scrappy-Doo | — | — | ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Scooby-Doo Mystery | — | Argonaut Games | Super Nintendo Entertainment System |
| SCORCH | action game | — | Microsoft Windows |
| Scorch | casual game | — | Microsoft Windows |
| Score! Hero | — | First Touch Games | Android |
| SCP - The Sentient Box | simulation video game, adventure video game | — | Microsoft Windows, macOS |
| SCP-087 Minecraft Edition | supernatural horror game | Invidec Games | Microsoft Windows |
| SCP: Abhorrent | action game | — | Microsoft Windows |
| SCP: Pandemic | tactical shooter, supernatural horror game | Affray Studios | Microsoft Windows, macOS, Linux |
| Scrabble | — | Electronic Arts, Stainless Games | Nintendo DS, PlayStation Portable |
| Scraper: Gauntlet | action game, strategy video game, role-playing video game | — | Microsoft Windows |
| Screamer 2 | — | Milestone S.r.l. | Microsoft Windows, macOS, Linux |
| Screamer 4x4 | racing video game | — | Microsoft Windows |
| Scribblenauts Unmasked: A DC Comics Adventure | crossover fiction, emergent gameplay | 5th Cell | Microsoft Windows, Wii U |
| Scriptum VR: The Neighbor's House Escape Room | adventure video game | — | Microsoft Windows |
| Scriptur | adventure video game | — | Microsoft Windows |
| SCRUMLORDS | adventure video game, action game, action-adventure game, strategy video game | — | Microsoft Windows |
| Scythe: Digital Edition | board video game, turn-based strategy video game, 4X | The Knights of Unity | Microsoft Windows, macOS, Android |
| SD Gundam: Over Galaxian | shooter game | — | — |
| SD Mobile Suit Gundam | action game | — | Super Nintendo Entertainment System |
| SD Rupan Sansei - Kinko yaburi daisakusen | action game | — | Game Boy |
| SD Shin Kamen Rider Rumble | beat 'em up | Winning Entertainment Group | Microsoft Windows |
| Sea Battle: Through the Ages | — | — | Microsoft Windows, macOS |
| Sea Dove | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Sea Of Fatness | — | — | Microsoft Windows, macOS, Linux |
| Seacurity Breach | — | Soaphog Game Studio | Microsoft Windows |
| SEARCH ALL - ANIMALS | casual game | Laush Studio | Microsoft Windows |
| SEARCH ALL - CANDY | casual game | Laush Studio | Microsoft Windows |
| SEARCH ALL - CHRISTMAS | casual game | Laush Studio | Microsoft Windows |
| SEARCH ALL - MUSHROOMS | casual game | Laush Studio | Microsoft Windows |
| Seas of Blood | — | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Seashell | — | High Tea Frog | Microsoft Windows |
| Seaside Driving | casual game, simulation video game, racing video game | — | Microsoft Windows |
| Season Match 4 | casual game, simulation video game, action game, strategy video game | — | Microsoft Windows |
| Secret Neighbor: Hello Neighbor Multiplayer | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Secret of the Silver Blades | tactical role-playing game | Strategic Simulations | Classic Mac OS, Microsoft Windows, DOS, Commodore 64 |
| Security Breach: Fury's Rage | side-scrolling beat 'em up | — | Microsoft Windows |
| Seek 2: Sadistic Babylon | eroge, visual novel | — | Microsoft Windows |
| Sega 3D Reprint Archives 3: Final Stage | — | — | Nintendo 3DS |
| Sega GT 2002 | racing video game | Sega Wow | — |
| Sega Mega Drive Classic Collection | — | Q122741 | Microsoft Windows, macOS, Linux |
| Sega Rally Revo | — | Sega Racing Studio | PlayStation 3, Microsoft Windows, PlayStation Portable |
| Sega Superstars Tennis | — | Sumo Digital | PlayStation 3, macOS, Nintendo DS, Wii |
| SegaSonic Cosmo Fighter | action game | Sega Wow | arcade video game machine |
| Seiken Psycho Caliber: Majū no Mori Densetsu | action role-playing game | — | Famicom Disk System |
| Seishun Fragile | eroge, visual novel | Purple software | Microsoft Windows |
| Sekai no Subete | eroge, visual novel | — | Microsoft Windows |
| Selenon Rising | visual novel | — | Microsoft Windows, macOS, Linux |
| Self-Delusion | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Selfloss | adventure video game | — | Microsoft Windows, Xbox Series X and Series S |
| Selma and the Wisp | platform game | — | Microsoft Windows, macOS, Linux |
| Sen megami ZERO | eroge, role-playing video game | Eushully | Microsoft Windows |
| Sengoku Hime 3: Tenka o Kirisaku Hikari to Kage | eroge, simulation video game, visual novel | — | PlayStation 3, Microsoft Windows, PlayStation Portable, PlayStation Vita |
| Sengoku Hime: Senran no Yo ni Honoo Tatsu | eroge, simulation video game, visual novel | — | Microsoft Windows, PlayStation Portable |
| Senran Kagura Burst Re:Newal | action game | Tamsoft, Honey Parade Games | Microsoft Windows |
| Senran Kagura: New Wave | card battle video game | — | Android |
| Sense Off ~A Sacred Story in the Wind~ | — | — | Microsoft Windows |
| Sensible World of Soccer '96/'97 | association football video game, sports video game | — | DOS |
| Sentinel | tower defense | Matthew Brown | Microsoft Windows, macOS, Linux |
| Sentinel 3: Homeworld | — | — | Microsoft Windows |
| Senua's Saga: Hellblade II | — | Ninja Theory | Microsoft Windows, Xbox Series X and Series S |
| Serial Cleaner | — | Draw Distance | Microsoft Windows, macOS, Linux |
| Serial Cleaners | stealth game | Draw Distance | Microsoft Windows, Xbox Series X and Series S |
| SERIES MAKERS TYCOON | casual game, simulation video game, strategy video game | — | Microsoft Windows |
| Serious Breakdown | action game | — | Microsoft Windows |
| Serious Sam 3: BFE | first-person shooter | Croteam | PlayStation 3, Microsoft Windows, macOS, Linux |
| Serious Sam 3: BFE Gold Edition | first-person shooter, action-adventure game | Croteam | Microsoft Windows, macOS, Linux |
| Serious Sam Classics: Revolution | first-person shooter | Croteam, Alligator Pit | Microsoft Windows |
| Serious Sam HD Gold Collection | first-person shooter, action-adventure game | Croteam, Alligator Pit | Microsoft Windows |
| Serious Sam HD: The Second Encounter - Legend of the Beast | — | — | Microsoft Windows |
| Serious Sam HD: The Second Encounter - Serious 8 DLC | — | Croteam | Microsoft Windows |
| Serious Sam VR Bundle | first-person shooter, action-adventure game | Croteam VR, Croteam | Microsoft Windows, Linux |
| Serious Sam VR: The First Encounter | first-person shooter, action-adventure game | Croteam VR, Croteam | Microsoft Windows, macOS, Linux |
| Serious Sam: Gold Edition | first-person shooter | Croteam, Alligator Pit | Microsoft Windows, Linux |
| Serious Savings | first-person shooter, action-adventure game | Timelock Studio, Croteam | Microsoft Windows |
| Server is Down | — | — | Microsoft Windows |
| Sesame Street Letters | — | Rare Ltd. | Nintendo Entertainment System |
| Sesame Street: Elmo Through The Looking Glass | adventure video game | — | Microsoft Windows |
| Session Seven | point-and-click adventure, adventure video game | — | Microsoft Windows, Linux |
| Seven Bullets Zombie Apocalypse | action game | — | Microsoft Windows |
| Sex | erotic video game | — | — |
| Sex Adventures - BDSM Dungeon | casual game | — | Microsoft Windows |
| Sex in the Sky | casual game, simulation video game, adventure video game, action game, action-adventure game, role-playing video game | — | Microsoft Windows |
| Sex Search 2: Ultimate | casual game | — | Microsoft Windows |
| Sex Simulator - Beach Resort | casual game, simulation video game | — | Microsoft Windows, Linux |
| Sex Simulator - The Yacht | casual game, simulation video game | — | Microsoft Windows, Linux |
| Sex Story - Ruby and Hunter - Episode 1 | casual game | — | Microsoft Windows, Linux |
| Sexy Space Airlines | casual game, business simulation game, incremental game, science fiction video game, erotic video game | Playduction | Microsoft Windows, Android |
| SGS Afrika Korps | simulation video game, strategy video game | — | Microsoft Windows, macOS |
| SGS Operation Hawaii | simulation video game, strategy video game | — | Microsoft Windows, macOS |
| Shadow Blade+ | — | — | — |
| Shadow Burglar | action game | — | Microsoft Windows |
| Shadow Fate | role-playing video game | — | Microsoft Windows |
| Shadow Fight | fighting game | Akella | Microsoft Windows |
| Shadow Fighter | — | — | Amiga 1200, Amiga CD32 |
| Shadow Force | beat 'em up | Technōs Japan | arcade video game machine |
| Shadow Hearts: From the New World | role-playing video game, video game with LGBT character | Sacnoth | — |
| Shadow Man Remastered | Metroidvania, adventure video game, action game, action-adventure game | Nightdive Studios | Microsoft Windows, Xbox Series X and Series S |
| Shadow Man: 2econd Coming | — | Acclaim Studios Teesside | — |
| Shadow Master | — | — | Microsoft Windows |
| Shadow of the Beast III | — | Ubisoft Reflections | — |
| Shadow Running | — | — | Microsoft Windows |
| Shadow: Treachery cannot be tolerated | — | — | Microsoft Windows |
| Shadowlands | — | — | DOS |
| Shadowrun | first-person shooter, cyberpunk video game | FASA Studio | Microsoft Windows |
| Shadowrun Returns | cyberpunk video game, role-playing video game | Behaviour Rotterdam, Harebrained Schemes | Microsoft Windows, macOS, Linux, Android, Xbox Series X and Series S |
| Shadowrun: Dragonfall - Director's Cut | tactical role-playing game | Behaviour Rotterdam, Harebrained Schemes | Microsoft Windows, macOS, Linux, Android, Xbox Series X and Series S |
| Shadowrun: Hong Kong - Extended Edition | adventure video game, strategy video game, role-playing video game | Behaviour Rotterdam, Harebrained Schemes | Microsoft Windows, Linux, Xbox Series X and Series S |
| Shadows Peak | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Shake It Up 2: Groove It Up | rhythm game | Papaya Studio | Wii |
| Shaken but Not Stirred | — | — | ZX Spectrum |
| Shamana Shamana: Tsuki to Kokoro to Taiyō no Mahō | eroge, visual novel | Caramel Box | Microsoft Windows |
| Shantae: Half-Genie Hero | platform game | WayForward Technologies | Microsoft Windows, PlayStation Vita, Wii U |
| Shapeshooter | rail shooter | NukGames | Microsoft Windows, Xbox Series X and Series S |
| Shardbound | — | — | Microsoft Windows |
| Shards of Azuria | — | — | Microsoft Windows |
| Sharin no Kuni: The Girl Among the Sunflowers | eroge, visual novel | Akabeisoft2 | PlayStation 3, Microsoft Windows |
| Shark Pinball | pinball video game | — | Microsoft Windows |
| Sharon and the Last Garden | action game | — | Microsoft Windows |
| Shashingo: Learn Japanese with Photography | photography game, educational video game | — | Microsoft Windows |
| Shattered Legacy | adventure video game | — | Microsoft Windows |
| Shattered Samurai | role-playing video game | — | Microsoft Windows |
| She Hates Unicorns | casual game, action game | — | Microsoft Windows |
| She Will Punish Them | role-playing video game | — | Microsoft Windows |
| She Will Shoot | casual game, simulation video game, adventure video game, action game, action-adventure game, role-playing video game | Boom Games | Microsoft Windows |
| Sheep | — | Mind's Eye Productions | Microsoft Windows, macOS |
| Sheepageddon | — | — | Microsoft Windows, macOS, Linux |
| Sheepo | platform game | Kyle Thompson | Microsoft Windows, Xbox Series X and Series S |
| Shellshock | — | Core Design | DOS |
| Shenmue I & II | adventure video game, role-playing video game | — | Microsoft Windows |
| Shenmue II | action-adventure game, role-playing video game | Sega AM2 | — |
| Shenmue Online | massively multiplayer online role-playing game | — | Microsoft Windows |
| Sherlock Holmes Versus Jack the Ripper | crossover fiction, adventure video game | Frogwares | Microsoft Windows |
| Sherlock Holmes: Consulting Detective Vol. III | interactive film, adventure video game | ICOM Simulations | Classic Mac OS, DOS |
| Sherlock Holmes: The Mystery of the Mummy | adventure video game | Frogwares | Microsoft Windows, Nintendo DS, Wii |
| Shibui Coliseum | action game | — | Microsoft Windows |
| Shield of Shalwend | action game | — | Microsoft Windows |
| Shijuu Hachi (Kari) | adventure video game | Arcadia Project | — |
| Shillelagh | action game | — | Microsoft Windows, macOS |
| Shimaima | eroge, visual novel | AliceSoft | Microsoft Windows |
| Shimano Xtreme Fishing | fishing video game | EV Interactive | Wii |
| Shin Bakusou Dekotora Densetsu | racing video game | — | — |
| Shin Galaxy - Engage | action game, role-playing video game | — | Microsoft Windows, Linux |
| Shin Hayarigami 2 | horror video game, urban fantasy video game, adventure video game, visual novel | rail transport in Malawi, Nippon Ichi Software | PlayStation 3, PlayStation Vita |
| Shin Hayarigami 3 | horror video game, urban fantasy video game, adventure video game, visual novel | Nippon Ichi Software | — |
| Shin Megami Tensei | post-apocalyptic video game, cyberpunk video game, role-playing video game | Q780528 | TurboGrafx-16, Super Nintendo Entertainment System, Android |
| Shin Megami Tensei: Devil Survivor 2 Record Breaker | tactical role-playing game | — | Nintendo 3DS |
| Shin SD Sengokuden Chou Kidou Daishougun | — | — | — |
| Shingoku no Valhalla Gate | role-playing video game | — | Android |
| Shining Force Gaiden | tactical role-playing game | Camelot Software Planning | — |
| Shining Hearts | role-playing video game | Q122741 | PlayStation Portable |
| Shining in the Darkness | role-playing video game | Climax Entertainment | Microsoft Windows, macOS, Linux |
| Shining Plume | casual game, adventure video game, strategy video game, role-playing video game | Warfare Studios | Microsoft Windows |
| Shining Soul II | action role-playing game | Q2585499 | — |
| Shining Tears | action role-playing game | Q2585499 | — |
| Shining Wisdom | action-adventure game | Camelot Software Planning | — |
| Shinobi | action game | Griptonite Games | Nintendo 3DS |
| Shinobi Ryū | eroge, simulation video game, visual novel | Softhouse Chara | Microsoft Windows |
| Ship Ahoy Open BETA | — | — | Microsoft Windows |
| Ship Graveyard Simulator | casual game, simulation video game, adventure video game, action game, action-adventure game, strategy video game | Incubator Games | Microsoft Windows, Xbox Series X and Series S |
| Ship Simulator Extremes | simulation video game | — | Microsoft Windows |
| Ship Simulator Realistic | casual game, simulation video game, massively multiplayer online game | — | Microsoft Windows |
| Shipwreck | — | Brushfire Games | Microsoft Windows, macOS, Linux |
| Shirazu Yama | action game | — | Microsoft Windows |
| Shiren the Wanderer GB2: Magic Castle of the Desert | roguelike | Chunsoft | Nintendo DS, Game Boy Color |
| Shiro | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Shirotsume Souwa -Episode of the Clovers- | visual novel | — | Microsoft Windows |
| Shishi : Timeless Prelude | casual game, adventure video game, role-playing video game | — | Microsoft Windows |
| Shock Troopers | shoot 'em up | Saurus | Neo Geo, Microsoft Windows, arcade video game machine |
| Shockway Rider | — | — | Amstrad CPC |
| Shoot. Push. Repeat. | casual game | Crew Lab | Microsoft Windows |
| Shooting Saucer | action game | — | Microsoft Windows |
| ShootOut(SystemD) | action game | — | Microsoft Windows |
| Shooty Fruity | — | — | Microsoft Windows |
| Shoppe Keep 2 | — | — | Microsoft Windows |
| Shopping Clutter 2: Christmas Square | casual game | Jetdogs Studios | Microsoft Windows, macOS |
| Shotgun King: The Final Checkmate | roguelike | — | Microsoft Windows, Linux, Xbox Series X and Series S |
| Shotgun Legend | action game, role-playing video game | — | Microsoft Windows |
| Shoujo kaisen | card video game | — | Android |
| Shoulders of Giants | action game, role-playing video game | Moving Pieces Interactive | Microsoft Windows, Xbox Series X and Series S |
| Show Me What You Got | — | — | Microsoft Windows |
| Showdown Bandit | — | — | Microsoft Windows |
| Showtime Championship Boxing | — | Nikitova Games | Nintendo DS, Wii |
| Shox | — | Electronic Arts | — |
| SHPR | casual game, adventure video game, action game, action-adventure game, strategy video game | — | Microsoft Windows |
| Shred! Remastered | — | ASBO Interactive | Xbox Series X and Series S |
| Shredders | snowboarding video game | FoamPunch, I-Illusions | Microsoft Windows, Xbox Series X and Series S |
| Shrek Forever After | action-adventure game | XPEC Entertainment | PlayStation 3, Microsoft Windows, Nintendo DS, Wii |
| Shrine of the God-Ape | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Shu | — | — | Microsoft Windows |
| Shuffle! Love Rainbow | eroge, visual novel | Navel | Microsoft Windows |
| Shugo Chara! Norinori! Chara na Rhythm | music video game | — | Nintendo DS |
| Shuten Order | — | Q56612484, Neilo | Microsoft Windows |
| Shuttle | — | Vektor Grafix | DOS |
| Shuzzler: The Word Game | casual game | — | Microsoft Windows |
| Shy Cats Hidden Orchestra | casual game | — | Microsoft Windows |
| Shy Eye Labyrinth: The Incredible Mystery | adventure video game | — | Microsoft Windows |
| Shūmatsu Shōjo Gensō Alicematic | eroge, visual novel | Caramel Box | Microsoft Windows |
| Siberian Strike | shoot 'em up, science fiction video game | — | mobile phone, Android |
| Sid Meier's Alpha Centauri | hard science fiction video game, turn-based strategy video game, 4X | Firaxis Games | Classic Mac OS, Microsoft Windows, macOS, Linux |
| Sid Meier's Pirates! | strategy video game | Firaxis Games | Microsoft Windows, macOS, PlayStation Portable, Windows Phone, Wii |
| Side by Size | strategy video game | — | Microsoft Windows |
| Sideral | — | — | Microsoft Windows, macOS |
| Siege of Treboulain | adventure video game, action game, action-adventure game, role-playing video game | Choice of Games | Microsoft Windows, macOS, Linux |
| Siege Survival: Gloria Victis | real-time strategy, survival game, strategy video game | — | Microsoft Windows |
| Sierra's 3-D Helicopter Simulator | helicopter simulation game, combat flight simulator game | — | DOS |
| Sightbringer | action game | — | Microsoft Windows |
| Signed and Sealed With a Kiss | — | — | Microsoft Windows, macOS, Linux |
| Signet City | — | Jump Over the Age | Microsoft Windows |
| Silence In The Cabin | action game | — | Microsoft Windows |
| Silent Hill: Ascension | survival horror | Q2080076 | web browser, Android |
| Silent Hill: HD Edition | — | — | PlayStation 3 |
| Silent Hill: Homecoming | psychological horror fiction | Double Helix Games | PlayStation 3, Microsoft Windows |
| Silent Hill: Origins | — | Climax Studios | PlayStation Portable |
| Silent Hunter 5: Battle of the Atlantic | submarine simulator | Ubisoft Romania | Microsoft Windows |
| Silent Service | submarine simulator | MicroProse | Apple IIGS, Microsoft Windows, macOS, DOS, Nintendo Entertainment System, ZX Spectrum, Linux, Amstrad CPC, Atari ST, Commodore 64 |
| Silent World | casual game, adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Silica | first-person shooter, real-time strategy | — | Microsoft Windows |
| Silicon Dreams | — | Level 9 Computing | Classic Mac OS, DOS, ZX Spectrum, Amstrad CPC, Amstrad PCW, MSX, Commodore 64 |
| Silk Roads: Caravan Kings | simulation video game, adventure video game | — | Microsoft Windows, macOS, Linux |
| Silver | — | — | Classic Mac OS, Microsoft Windows, macOS, Linux |
| Silver Chains | horror video game | Cracked Heads Games | Microsoft Windows, Xbox Series X and Series S |
| Silver Screen Story | simulation video game | Kairosoft | Microsoft Windows |
| Silver Surfer | — | Software Creations | Nintendo Entertainment System |
| SilverLoad | — | — | DOS |
| Silverworld | adventure video game, role-playing video game | Choice of Games | Microsoft Windows, macOS, Linux |
| Silvestrovská pecka | text-based video game, adventure video game | — | ZX Spectrum, Didaktik |
| SimCity | construction and management simulation, science fiction video game, city-building game, massively multiplayer online game | Maxis | Microsoft Windows, macOS |
| SimCity | — | Maxis | — |
| SimCity 2000: Scenarios Volume I: Great Disasters | city-building game | Maxis | Classic Mac OS, Microsoft Windows, DOS, NEC PC-9800 series |
| SimCity 3000 | construction and management simulation, city-building game | Maxis | Classic Mac OS, Microsoft Windows, macOS, Linux, Android |
| SimCity BuildIt | city-building game | — | Android |
| SimCity Creator | city-building game | Hudson Soft | Wii |
| SimFarm | construction and management simulation | Maxis | Classic Mac OS, Microsoft Windows, DOS |
| Similars: Climb | casual game, action game | — | Microsoft Windows |
| Simon Tatham's Portable Puzzle Collection | — | — | — |
| Simon the Sorcerer 3D | — | Headfirst Productions | Microsoft Windows |
| Simple 1500 Jitsuyou Series Vol. 01: Norikae Annai: 2000-nenban | — | — | — |
| Simple 1500 Jitsuyou Series Vol. 02: Katei no Fuusui | — | — | — |
| Simple 1500 Jitsuyou Series Vol. 03: Seimei Handan | — | — | — |
| Simple 1500 Jitsuyou Series Vol. 06: Cocktail no Recipe | — | — | — |
| Simple 1500 Jitsuyou Series Vol. 07: Tanoshiku Manabu Unten Menkyo | — | — | — |
| Simple 1500 Jitsuyou Series Vol. 08: 1-jikan de Wakaru Kabushiki Toushi | — | — | — |
| Simple 1500 Jitsuyou Series Vol. 15: Inu no Kai-kata: Sekai no Inu Catalog | — | — | — |
| Simple 1500 Jitsuyou Series Vol. 18: Kanji Quiz: Kanji Kentei ni Challenge | — | — | — |
| Simply Mahjong | puzzle video game | Engine Software | Nintendo DSi |
| Simply Solitaire | puzzle video game | Engine Software, Cypronia | Nintendo DSi |
| SimPocalypse | casual game, simulation video game, adventure video game, strategy video game, role-playing video game | — | Microsoft Windows, Linux |
| SimTown | simulation video game, city-building game | Maxis | Classic Mac OS, Microsoft Windows, Super Nintendo Entertainment System |
| Sin and Punishment | shoot 'em up, rail shooter, science fiction video game | Treasure, Nintendo Research & Development 1 | Nintendo 64, Wii U |
| SINce Memories: Off the Starry Sky | romance video game | Mages | Microsoft Windows |
| Sine Mora EX | shoot 'em up | — | Microsoft Windows |
| SingStar Guitar | — | London Studio | PlayStation 3 |
| SingStar The Dome | — | — | — |
| Singularity | first-person shooter, science fiction video game | Raven Software | PlayStation 3, Microsoft Windows |
| Sink King | arcade, puzzle video game | — | MSX |
| Sink or Swim | — | Eutechnyx | DOS, Super Nintendo Entertainment System |
| Sins of a Solar Empire | space opera video game, real-time strategy | Ironclad Games | Microsoft Windows |
| Sir Questionnaire | adventure video game, role-playing video game | Orange Pixel | Microsoft Windows, Linux |
| Sir, You Are Being Hunted | — | Big Robot | Microsoft Windows, macOS, Linux |
| Siralim | role-playing video game | Thylacine Studios | Microsoft Windows, macOS, Linux |
| Siralim 2 | role-playing video game | Thylacine Studios | Microsoft Windows, macOS, PlayStation Vita, Linux, Android |
| Siralim 3 | role-playing video game | Thylacine Studios | Microsoft Windows, macOS, Linux, Android |
| Skate | skateboarding video game | EA Vancouver | PlayStation 3 |
| Skate or Die 2: The Search for Double Trouble | skateboarding video game | Electronic Arts | Nintendo Entertainment System |
| Skate Story | skateboarding video game | — | Microsoft Windows, macOS |
| Skatin' USA | — | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Skator Gator 3D | adventure video game, action game, action-adventure game, sports video game | — | Microsoft Windows |
| Skautfold: Usurper | action game, role-playing video game | — | Microsoft Windows |
| Skelets | action game | Sokpop Collective | Microsoft Windows, macOS |
| Ski Crazed | skiing video game | Naughty Dog | Apple II series |
| Skidmarks | — | Acid Software | — |
| Skidz | — | Core Design | Atari ST |
| Skipper & Skeeto: Tales from Paradise Park | — | Ivanoff Interactive | Microsoft Windows |
| Skipper & Skeeto: The Number Shop | educational video game | Ivanoff Interactive | Microsoft Windows |
| Skipper & Skeeto: The Revenge of Mr. Shade | point-and-click adventure | Ivanoff Interactive | Microsoft Windows |
| Skjoldur Story | adventure video game, action game, action-adventure game, role-playing video game | — | Microsoft Windows |
| Skribbl | drawing | — | web browser |
| Skull Fang | shoot 'em up | Data East | arcade video game machine |
| Skully | platform game | Finish Line Games | Microsoft Windows |
| Sky Conqueror | — | — | Microsoft Windows |
| Sky Goddess | — | — | Microsoft Windows |
| Sky High Games Horror Collection | simulation video game, adventure video game | — | Microsoft Windows |
| SKY JUMP | adventure video game | — | Microsoft Windows |
| Sky Pirates of Actorius | adventure video game, role-playing video game | Choice of Games | Microsoft Windows, macOS, Linux |
| Sky Sanctuary | — | — | Microsoft Windows |
| Sky Shepherd | — | — | Microsoft Windows |
| Sky Surfer | — | Toka | — |
| Sky Tale | casual game, city-building game | FrostPeek Studio | Microsoft Windows, macOS |
| Sky to Fly: Soulless Leviathan | simulation video game, adventure video game, action game, action-adventure game, racing video game, sports video game | AIVIK LLC | Microsoft Windows, macOS, Linux |
| Skybolt Zack | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Skyhammer | — | Rebellion Developments | Atari Jaguar |
| Skylanders: Imaginators | action-adventure game | Toys for Bob | Wii U |
| Skyscraper Simulator | simulation video game | — | Microsoft Windows |
| Skyscrappers | — | Ground Shatter | Microsoft Windows, macOS, Linux |
| Slabs | — | — | Microsoft Windows |
| SLAMMED! | role-playing video game | Choice of Games | Microsoft Windows, macOS, Linux |
| Slap City | fighting game | — | Microsoft Windows |
| Slave Ghost | casual game, adventure video game | — | Microsoft Windows |
| Slave Maker 2 | eroge, parody video game | — | — |
| Slave's Sword | adventure video game, role-playing video game | — | Microsoft Windows |
| Slave's Sword 2 | role-playing video game | — | Microsoft Windows |
| SleepWalker | puzzle video game | — | Microsoft Windows |
| Slender: The Arrival | psychological horror fiction | Blue Isle Studios | PlayStation 3, Microsoft Windows, macOS, Wii U, Xbox Series X and Series S |
| Slenderman's Shadow | survival horror | Marc Steene, Wray Burgess | Microsoft Windows, macOS, Linux |
| Slendrina: The Cellar | horror video game | — | Microsoft Windows, Android |
| Slide to finish | — | — | Microsoft Windows |
| Slightly Heroes VR | casual game, action game | — | Microsoft Windows |
| Slime Time TD | — | — | Microsoft Windows |
| Slime's Revenge | adventure video game, action game, action-adventure game, role-playing video game | — | Microsoft Windows |
| Slippery Flippers: Episode One - Amulet of the Gods | casual game, simulation video game, adventure video game | — | Microsoft Windows, macOS, Linux |
| Slow Roads | simulation video game | — | web browser |
| Sly 3: Honor Among Thieves | platform game | Sanzaru Games | PlayStation 3, PlayStation Vita |
| Small Dark House Survival | — | — | Microsoft Windows |
| Smart Bomb | — | Core Design | PlayStation Portable |
| Smarties: Meltdown | — | Europress | — |
| Smash Court Tennis Pro Tournament 2 | tennis video game | Namco | — |
| SMASH IT | — | — | Microsoft Windows |
| Smash Tennis | tennis video game | Namco | Super Nintendo Entertainment System |
| Smash Up | — | Nomad Games | Microsoft Windows |
| Smasher and the Will o' the Thiccs | casual game | — | Microsoft Windows |
| SmFly: Gravity Adventure | casual game, adventure video game, action game, action-adventure game | Dnovel | Microsoft Windows |
| Smite | multiplayer online battle arena, action game, shooter game | Hi-Rez Studios | Microsoft Windows, Xbox Series X and Series S |
| Smurfs Kart | kart racing game | — | Microsoft Windows, Xbox Series X and Series S |
| Smysl 2 gravity | — | — | Microsoft Windows |
| Snail Bob 2 | puzzle video game | — | Microsoft Windows, macOS, Android |
| Snake | action game | — | Microsoft Windows, Linux, TRS-80 Model I |
| Snake | action game | — | — |
| Snake Deluxe | casual game, action game | — | Microsoft Windows |
| Snake's Revenge | stealth game | Konami | Nintendo Entertainment System |
| Snakeball | action game | — | PlayStation 3 |
| Snezhinka: Sentinel Girls 2 | shooter game | — | Microsoft Windows, Xbox Series X and Series S |
| Snipe Hunt | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Sniper Elite 5 | — | Rebellion Developments | Microsoft Windows, macOS, Xbox Series X and Series S |
| Sniper Elite 5 Deluxe Edition | — | Rebellion Developments | Microsoft Windows, Xbox Series X and Series S |
| Sniper Elite V2 Remastered | — | Rebellion Developments | Microsoft Windows |
| Sniper Elite: Resistance | — | Rebellion Developments | Microsoft Windows, Xbox Series X and Series S |
| Snoopy Tennis | — | — | Game Boy Color |
| Snow Bros. Nick and Tom Special | platform game | CRT GAMES | — |
| Snow Clearing Driving Simulator | casual game, simulation video game, racing video game, sports video game | A Nostru | Microsoft Windows |
| Snow Sakura | eroge, visual novel | — | Microsoft Windows |
| Snow White Solitaire. Charmed Kingdom | casual game, adventure video game | — | Microsoft Windows, macOS |
| Snow White Solitaire. Legacy of Dwarves | casual game, adventure video game | — | Microsoft Windows, macOS |
| Snow White: Happily Ever After | — | Q1469961 | Super Nintendo Entertainment System |
| Snow-Swept Quest | adventure video game, role-playing video game | — | Microsoft Windows |
| Snowy: Space Trip | — | Aliasworlds Entertainment | — |
| Snowy: The Bear's Adventures | platform game | Aliasworlds Entertainment | PlayStation 3, Microsoft Windows, macOS, PlayStation Portable, PlayStation Vita |
| Snowy: Treasure Hunter | — | Aliasworlds Entertainment | — |
| Snowy: Treasure Hunter 2 | — | Aliasworlds Entertainment | — |
| Soccer Manager 2016 | — | — | Microsoft Windows, macOS |
| Soccer Manager 2017 | — | — | Microsoft Windows, macOS |
| Soccer Manager 2020 | sports video game | — | Microsoft Windows |
| Soccer Manager 2021 | — | — | Microsoft Windows |
| Soccer Manager 2024 | — | — | Android |
| Social Credit Simulator | casual game, simulation video game | — | Microsoft Windows |
| Socialize | massively multiplayer online role-playing game | — | Microsoft Windows |
| Soda Crisis | shoot 'em up, side-scrolling video game | Team Soda | Microsoft Windows |
| SOK MIN | casual game | — | Microsoft Windows |
| Sok-stories | casual game | Sokpop Collective | Microsoft Windows, macOS |
| Sokbots | action game | Sokpop Collective | Microsoft Windows, macOS |
| Sokoban Land DX | casual game, adventure video game | lightUP | Microsoft Windows |
| Sokobear: Goo | casual game | — | Microsoft Windows |
| Sokocat: Combo | puzzle video game | — | Xbox Series X and Series S |
| Sol 705 | casual game, adventure video game | — | Microsoft Windows, macOS, Linux |
| SOL MOONARGE | — | — | — |
| Solar Assault | shoot 'em up | Konami | arcade video game machine |
| Soldier Blade | shoot 'em up | Hudson Soft | TurboGrafx-16, Wii U |
| Soldier of Fortune | first-person shooter, science fiction video game | Raven Software | Microsoft Windows, Linux |
| Solitaire Antics | solitaire video game | Ant Software | Classic Mac OS, Microsoft Windows |
| Solitaire Beach Season 3 | — | Creobit | Microsoft Windows |
| Solitaire Beautiful Garden Season | casual game | Magnussoft | Microsoft Windows |
| Solitaire FunPak | — | — | — |
| Solitaire Jack Frost Winter Adventures | — | Somer Games | Microsoft Windows, macOS |
| Solitaire Legend of the Pirates 2 | — | Somer Games | Microsoft Windows |
| Solitaire TED and PET | — | Somer Games | Microsoft Windows |
| Solitaire Victorian Picnic | — | Big Up Studio | Microsoft Windows, macOS |
| Solitaire. Dragon Light | casual game | — | Microsoft Windows, macOS |
| Solomon's Key | crossover fiction, puzzle video game | Tecmo | Famicom Disk System, DOS, Nintendo Entertainment System, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Solstice | — | Software Creations | Nintendo Entertainment System |
| Something Ate My Alien | puzzle video game | — | Microsoft Windows, macOS, Linux |
| Sometimes: Success Requires Sacrifice | — | Volens Nolens Games | Microsoft Windows |
| Somewhere in a Clay Nowhere | action game | — | Microsoft Windows |
| Son of a Witch | adventure video game, action game, action-adventure game | — | Microsoft Windows, macOS, Linux |
| Song Beater: Quite My Tempo! | casual game, action game | — | Microsoft Windows |
| Songbird Symphony | — | — | Microsoft Windows, macOS |
| SongPop | music video game | — | Android |
| Sonic Advance 3 | platform game | Sonic Team, Dimps | Wii U |
| Sonic Blast Man | beat 'em up | Taito | Super Nintendo Entertainment System, arcade video game machine |
| Sonic Blast Man II | beat 'em up | — | Super Nintendo Entertainment System |
| Sonic Drift | racing video game | Q122741 | — |
| Sonic Drift 2 | racing video game | Q122741 | — |
| Sonic Generations | action-adventure game | Sonic Team, Dimps | Nintendo 3DS |
| Sonic Jam | platform game | Sonic Team | — |
| Sonic Mega Collection | action game, pinball video game, beat 'em up, puzzle video game, platform game | Sonic Team | Microsoft Windows, Nintendo GameCube |
| Sonic Pinball Party | crossover fiction, action game, pinball video game | Sonic Team | — |
| Sonic Rivals 2 | action game | Q122741, Q389261 | PlayStation Portable |
| Sonic the Hedgehog 4: Episode II | platform game | Sonic Team | PlayStation 3, Microsoft Windows, PlayStation Portable, Windows Phone, Android |
| Sonic the Hedgehog CD | platform game | Sonic Team | Microsoft Windows, PlayStation Portable, Nintendo GameCube, Android |
| Sonic the Hedgehog Pocket Adventure | platform game | SNK | — |
| Sonic Wings Reunion | shoot 'em up | Success | Microsoft Windows, arcade video game machine |
| Sonic Wings Special | shooter game | Video System | arcade video game machine |
| Sonny | role-playing video game | — | Microsoft Windows, macOS |
| Sophie's Dice | simulation video game | — | Microsoft Windows, macOS, Linux |
| Sora | bullet hell | — | Microsoft Windows |
| Sorcery Blade | — | WorldWideSoftware | Wii |
| Sordwin: The Evertree Saga | adventure video game, role-playing video game | Hosted Games | Microsoft Windows, macOS, Linux |
| Sorority Rites | psychological horror fiction, visual novel | AppSir | Microsoft Windows, Android |
| Soul Hackers 2 | role-playing video game | Q780528 | Microsoft Windows, Xbox Series X and Series S |
| Soul of a Robot | — | — | ZX Spectrum, Amstrad CPC, MSX |
| Soul Survivor: Trials of the Goddess | role-playing video game | — | Microsoft Windows |
| Soul-Ivy: C0 | — | — | Microsoft Windows, macOS |
| Soulcalibur II | 3D fighting game, crossover fiction | Project Soul | PlayStation 3, Nintendo GameCube, arcade video game machine |
| Soulcalibur V | 3D fighting game | Project Soul | PlayStation 3 |
| Souls of the Wind | adventure video game, role-playing video game | — | Microsoft Windows |
| Soulscape | — | — | Microsoft Windows |
| SOUND VOLTEX EXCEED GEAR | rhythm game | — | arcade video game machine |
| Sound Voltex II: Infinite Infection | rhythm game | — | arcade video game machine |
| Sound Voltex III: Gravity Wars | rhythm game | — | arcade video game machine |
| South Park: Chef's Luv Shack | party video game | Acclaim Studios Austin | Microsoft Windows, Nintendo 64 |
| Southern Belle | — | Hewson Consultants | ZX Spectrum, Amstrad CPC, Amstrad PCW, Commodore 64 |
| Sovereign Tower | — | — | Microsoft Windows, Linux |
| SPACE BANDITOS | action game | — | Microsoft Windows |
| Space Battle VR | action game | — | Microsoft Windows |
| Space Bust-a-Move | puzzle video game | — | Nintendo DS |
| SPACE Craft | adventure video game, action game, action-adventure game, role-playing video game | Enoops | Microsoft Windows |
| SPACE DANCE | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Space Engineers | simulation video game, sandbox game, strategy video game | Keen Software House | Microsoft Windows |
| Space Escape! | casual game, simulation video game, action game | — | Microsoft Windows |
| Space Farmers | — | — | Microsoft Windows, macOS, Linux |
| Space Flowers | strategy video game | — | Microsoft Windows |
| Space Food Truck | strategy video game | — | Microsoft Windows, macOS, Linux |
| Space Funeral | — | Stephen Gillmurphy | Microsoft Windows |
| Space Gladiators: The Hole | action game | — | Microsoft Windows |
| Space God | casual game, action game | — | Microsoft Windows, macOS, Linux |
| Space Harrier | shoot 'em up, rail shooter | Sega AM2 | TurboGrafx-16, Nintendo Entertainment System, arcade video game machine, Nintendo 3DS, ZX Spectrum, Amstrad CPC, Atari ST +1 |
| Space Haters | — | — | Microsoft Windows |
| Space Intervention | casual game | — | Microsoft Windows, Nintendo 3DS, Wii U |
| Space Invaders | fixed shooter | Taito | Atari 2600 |
| Space Invaders Extreme 2 | shooter game | — | Nintendo DS |
| Space Invaders Invincible Collection | — | Gotch Technology Corp. | — |
| Space Invaders: Fukkatsu no Hi | fixed shooter | Taito | TurboGrafx-16, Wii |
| Space Journey | simulation video game, adventure video game, action game, action-adventure game | — | Microsoft Windows, macOS |
| Space Kettle | casual game, adventure video game, action game, action-adventure game | — | Microsoft Windows, macOS |
| Space landing | casual game, adventure video game | — | Microsoft Windows |
| Space Marines: The Steel Emperor | strategy video game | Software 2000 | DOS |
| Space Maxwell: Arcade | casual game, action game | — | Microsoft Windows |
| Space Pilgrim Academy: Year 2 | adventure video game | Pilgrim Adventures | Microsoft Windows |
| Space Punks | action role-playing game | — | Microsoft Windows |
| Space Quest I: Roger Wilco in the Sarien Encounter | — | — | Microsoft Windows |
| Space Quest V | adventure video game | — | Microsoft Windows, DOS |
| Space Rangers 2: Reboot | — | SNK-Games, Elemental Games, Katauri Interactive | Microsoft Windows |
| Space Robinson: Hardcore Roguelike Action | adventure video game, action game, action-adventure game, role-playing video game | — | Microsoft Windows, macOS, Linux |
| Space Tower Defense | — | — | Microsoft Windows |
| Space, VR! | — | — | Microsoft Windows |
| Spacebase Startopia | simulation video game | Realmforge Studios | Microsoft Windows, macOS, Linux |
| Spacepowers | — | — | Microsoft Windows, macOS |
| Spacewing War | action game | Eastasiasoft | Microsoft Windows, Xbox Series X and Series S |
| Sparrow Solitaire | — | — | — |
| Spate | — | — | Microsoft Windows, macOS, Linux |
| Spearmint Goose | — | — | Microsoft Windows |
| Spec Ops: Ranger Team Bravo | tactical shooter | Zombie Studios | Microsoft Windows |
| Spec Ops: Rangers Lead the Way | tactical shooter | Zombie Studios | Microsoft Windows |
| Special Forces | — | Sleepless Knights | DOS, Atari ST |
| Spectator | casual game, simulation video game, action game | — | Microsoft Windows, macOS, Linux |
| Spectrobes | action role-playing game | Jupiter | Nintendo DS |
| Spectrolite | action game | — | Microsoft Windows |
| Spectromancer | turn-based strategy video game, card video game, fantasy video game | Apus Software | Microsoft Windows |
| Spectrum | — | — | Microsoft Windows, macOS, Linux, Android |
| Speed Kings | — | Climax Studios | Nintendo GameCube |
| Speed Racing Ultimate | racing video game | Dream-Up | Android |
| Speedboat Attack | — | Criterion Games | Microsoft Windows |
| Speeder | — | — | Microsoft Windows |
| Speedway Racing | simulation video game, racing video game, sports video game | Super PowerUp Games | Microsoft Windows, Xbox Series X and Series S |
| Spell Swap | action game | — | Microsoft Windows |
| Spell Sweeper | casual game | — | Microsoft Windows |
| Spellarium 7 - Match 3 Puzzle | casual game | LGT SIA | Microsoft Windows |
| Spellbearers | adventure video game, action game, action-adventure game, strategy video game, role-playing video game | — | Microsoft Windows |
| Spellbound | — | David Jones | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Spellbound | — | — | ZX Spectrum |
| SpellForce 2: Shadow Wars | role-playing video game | EA Phenomic | Microsoft Windows |
| SpellForce 3: Fallen God | strategy video game, role-playing video game | Grimlore Games | Microsoft Windows |
| SpellForce III Reforced: Complete Edition | — | Grimlore Games | Xbox Series X and Series S |
| Spelljammer: Pirates of Realmspace | tactical role-playing game, adventure video game, strategy video game, role-playing video game | — | Microsoft Windows, DOS |
| SpellTower+ | — | Zach Gage | — |
| Spelunker II: Yūsha e no Chōsen | platform game | Now Production | Nintendo Entertainment System |
| Spelunky 2 | roguelike | Mossmouth, Derek Yu, Q41974894 | Microsoft Windows, Xbox Series X and Series S |
| Spencer | casual game, action game | — | Microsoft Windows |
| Spherical alliance | casual game, action game, strategy video game | — | Microsoft Windows, macOS |
| Spice and Wolf VR | incremental game, visual novel | — | Microsoft Windows |
| Spice World | — | London Studio | — |
| SPICESHIFTER | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Spider | casual game, strategy video game | — | Microsoft Windows |
| Spider Fear | action game | — | Microsoft Windows |
| Spider Lander | — | — | Microsoft Windows |
| Spider-Man and the X-Men in Arcade's Revenge | — | Software Creations | Super Nintendo Entertainment System, Game Boy |
| Spider-Man and Venom: Maximum Carnage | — | Software Creations | Super Nintendo Entertainment System |
| Spidersaurs | platform game | WayForward Technologies | Microsoft Windows, Xbox Series X and Series S |
| Spindizzy | — | Electric Dreams Software | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Spindizzy Worlds | — | — | Super Nintendo Entertainment System, Atari ST |
| Spinner Invaders | action game | — | Microsoft Windows |
| Spinning_Kid_2 | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Spirit Guide Crucible | — | IndieRevo | Microsoft Windows |
| Spirit Hunter: Death Mark | visual novel | Experience | Microsoft Windows, PlayStation Vita |