| Z Runaway | — | For Kids | Microsoft Windows, macOS, Linux |
| ZACH-LIKE | puzzle video game | Zachtronics | Microsoft Windows |
| Zamboni Simulator 2019 | simulation video game | — | Microsoft Windows, macOS |
| Zang Hua - Anhei Taohuayuan | interactive fiction | Zerocreation Games | Microsoft Windows, Android |
| Zankinzoken | casual game, action game | — | Microsoft Windows |
| Zansho Omimai Mōshiagemasu | eroge, visual novel | — | Microsoft Windows |
| Zaxxon's Motherbase 2000 | shoot 'em up, action game | Q122741, CRI Middleware | — |
| Zball II | — | — | Microsoft Windows |
| ZCREW | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| ZED | casual game, adventure video game | Eagre Games | Microsoft Windows, macOS, Linux |
| Zeebo Extreme Jetboard | sports video game | Tectoy | Zeebo |
| Zeebo Extreme Rolimã | racing video game | Tectoy | Zeebo |
| Zelda | action-adventure game | Nintendo | Game & Watch series |
| Zen Pinball Party | pinball video game | — | macOS |
| Zeno Clash | first-person shooter, fighting game | ACE Team | Microsoft Windows |
| Zero Escape: The Nonary Games | escape room video game, adventure video game, visual novel | Spike Chunsoft | Microsoft Windows, PlayStation Vita, Xbox Series X and Series S |
| Zero Hour | first-person shooter | — | Microsoft Windows, Xbox Series X and Series S |
| Zero Infinity -Devil of Maxwell- | visual novel | — | Microsoft Windows |
| Zero Racers | racing video game | — | Virtual Boy |
| Zero4 Champ Series: Drift Champ | racing video game | — | — |
| Zeroptian Invasion | action game | — | Microsoft Windows |
| Zeus Quest: The Rebirth of Earth | point-and-click adventure | Crazysoft | Microsoft Windows, macOS, Linux, Xbox Series X and Series S |
| ZHEROS | action game | — | Microsoft Windows |
| Zhmurki | arcade | Gaijin Entertainment | Microsoft Windows |
| Zhmyshenko Valery Albertovich | casual game, adventure video game | — | Microsoft Windows |
| Zid Journey | adventure video game | — | — |
| Zig | — | — | Microsoft Windows, macOS, Linux |
| Zill O'll Infinite | role-playing video game | Koei Tecmo Holdings | — |
| Zoda's Revenge: StarTropics II | action-adventure game | Nintendo development teams | Nintendo Entertainment System |
| Zodiac DX | action game | — | Microsoft Windows |
| Zodiacats | puzzle video game | Devcats | Microsoft Windows, Linux |
| Zoids mokushiroku | — | — | Nintendo Entertainment System |
| Zoids Struggle | fighting game | — | — |
| Zom-bie, or Not Zom-bie | — | — | Microsoft Windows |
| Zombie Army Trilogy | — | Rebellion Developments | Microsoft Windows |
| Zombie Birds First Encounter Halloween | casual game, action game | Magnussoft | Microsoft Windows |
| Zombie Derby 2 | racing video game | — | Microsoft Windows |
| Zombie Derby: Pixel Survival | racing video game | Brinemedia | Microsoft Windows, Xbox Series X and Series S |
| Zombie Drift | casual game, action game, racing video game | — | Microsoft Windows |
| Zombie Estate 2 | — | — | Microsoft Windows |
| Zombie Hill Racing | — | InLogic Software | Microsoft Windows, Android, Xbox Series X and Series S |
| Zombie Maze | casual game | Quarlellle | Microsoft Windows |
| Zombie Panic! Source | first-person shooter | Zombie Panic Team | Microsoft Windows, Linux |
| Zombie Rush : Extinction | — | — | Microsoft Windows |
| Zombie Solitaire 2 Chapter 1 | casual game | — | Microsoft Windows |
| Zombie Zoeds | adventure video game | MysticGames | Microsoft Windows |
| Zombien | adventure video game, role-playing video game | Hosted Games | Microsoft Windows, macOS, Linux |
| Zombo Buster Rising | action game | Firebeast | Microsoft Windows, macOS, Linux, Xbox Series X and Series S |
| Zomcade | action game | — | Microsoft Windows |
| Zone of the Enders | hack and slash, mecha video game, third-person shooter | Konami | PlayStation 3 |
| Zoo 2: Animal Park | casual game, simulation video game | King Art Games | Microsoft Windows |
| Zoo Hospital | — | Torus Games | Nintendo DS, Wii |
| Zoo Packs | action game, strategy video game | Sokpop Collective | Microsoft Windows, macOS |
| Zoo Tycoon | — | Frontier Developments | — |
| ZooKeeper | casual game, simulation video game, adventure video game, action game, action-adventure game, strategy video game | Pyramid Games | Microsoft Windows |
| Zoological Era II | role-playing video game | — | Microsoft Windows |
| Zork: The Undiscovered Underground | adventure video game | — | Classic Mac OS, Microsoft Windows, Commodore 64 |
| Zorro The Chronicles | action game | BKOM Studios | Microsoft Windows, Xbox Series X and Series S |
| Zortch | boomer shooter | — | Microsoft Windows |
| Zorya: The Celestial Sisters | puzzle video game | — | Microsoft Windows |
| Zuma | Puzz Loop clone, puzzle video game, tile-matching video game | Oberon Media | PlayStation 3, Microsoft Windows, macOS |
| Zup! 5 | casual game, puzzle video game | Quiet River | Microsoft Windows |
| Zup! 9 | casual game, puzzle video game | Quiet River | Microsoft Windows |