| E-Racer | — | Rage Games | Microsoft Windows |
| EA Sports College Football 25 | American football video game, sports video game | EA Orlando | Xbox Series X and Series S |
| EA Sports PGA Tour | golf video game | EA Orlando | Microsoft Windows, Xbox Series X and Series S |
| EA Sports UFC | fighting game | EA Vancouver | Android |
| EA Sports UFC 2 | mixed martial arts video game | EA Vancouver | — |
| Each Other | strategy video game | — | Microsoft Windows |
| Eador: Genesis | turn-based strategy video game, role-playing video game | — | Microsoft Windows |
| Eagle Simulator | — | — | Microsoft Windows |
| EAGLETALON vs. HORDE OF THE FLIES | casual game | — | Microsoft Windows |
| Earth Defense Force: World Brothers 2 | third-person shooter | Yuke's | Microsoft Windows |
| Earth Elements | strategy video game | — | Microsoft Windows |
| Earth Guard: Egypt | action game | — | Microsoft Windows |
| EarthNight | platform game | — | Microsoft Windows, macOS |
| Earthworm Jim | platform game | Shiny Entertainment | PlayStation Portable |
| Earthworm Jim 3D | — | VIS Entertainment | Microsoft Windows, Nintendo 64 |
| Earthworm Jim HD | platform game | Gameloft | — |
| Eason | — | — | Microsoft Windows |
| East Tower - Kurenai | visual novel | Roseverte | Microsoft Windows, macOS |
| Easter Eggstravaganza | — | — | Microsoft Windows |
| Eastern Exorcist | adventure video game, action game, action-adventure game, role-playing video game | — | Microsoft Windows |
| Eastside Hockey Manager | — | Sports Interactive | Microsoft Windows |
| Easy Come Easy Golf | golf video game | Clap Hanz, Clarendon Township | macOS |
| Easy puzzle: Landscape | casual game | Laush Studio | Microsoft Windows |
| Ecchi Jack | — | — | Microsoft Windows |
| Ecchi Spirit | — | — | Microsoft Windows |
| Ecco the Dolphin | science fiction video game, platform game | Novotrade | Microsoft Windows, macOS, Linux |
| Echo Generation | adventure video game | Cococucumber | Microsoft Windows, Xbox Series X and Series S |
| Echochrome II | puzzle video game | Japan Studio | PlayStation 3 |
| ECHOES OF WAR: The Last Heartbeat | — | — | Microsoft Windows |
| Eco | — | Denton Designs | Atari ST |
| ED-IT | — | — | Microsoft Windows |
| Edengate: The Edge of Life | casual game, adventure video game | Hook | Microsoft Windows, Xbox Series X and Series S |
| Edens Zero | action role-playing game | Konami | Microsoft Windows, Xbox Series X and Series S |
| Edens Zero: Pocket Galaxy | action role-playing game | — | Android |
| Edge of Reality: Lost Secrets of the Forest Collector's Edition | casual game, adventure video game | — | Microsoft Windows |
| EdgeOfTheAbyssAwaken | action game, strategy video game, role-playing video game | — | Microsoft Windows |
| Eggerland Mystery | puzzle video game | HAL Laboratory | MSX |
| Egglia: Rebirth | role-playing video game | — | — |
| Egypt Picross Pharaohs Riddles | — | Somer Games | Microsoft Windows |
| Eight Dragons | casual game, action game | — | Microsoft Windows, Linux |
| Einherjar | strategy video game | — | Microsoft Windows |
| Eisei Meijin | puzzle video game | — | — |
| El Chavo | party video game | Kaxan Games | Wii |
| Elden Ring Nightreign | action roguelike, role-playing video game | FromSoftware | Microsoft Windows, Xbox Series X and Series S |
| Elderand | adventure video game, action game, action-adventure game, role-playing video game | — | Microsoft Windows |
| Elections Simulator 2018 | simulation video game | Cranberry Software | Microsoft Windows |
| Electric | — | — | Microsoft Windows |
| Electromaze Tower Defense | strategy video game | — | Microsoft Windows |
| Electronic Super Joy: Groove City | — | — | Microsoft Windows, macOS, Linux, Wii U |
| Electronic World Z | casual game, adventure video game | Anamik Majumdar | Microsoft Windows, Linux |
| Elektrosoul | casual game, strategy video game | — | Microsoft Windows, Linux |
| Elemental Angel Ⅱ | — | — | Microsoft Windows |
| Elemental War | tower defense | Clockwork Origins | Microsoft Windows, macOS, Linux, Xbox Series X and Series S |
| Elemental War 2 | tower defense, strategy video game | Clockwork Origins | Microsoft Windows, macOS, Linux, Xbox Series X and Series S |
| Elementary My Dear Majesty! | casual game | — | Microsoft Windows, macOS |
| Elements of Dreams | adventure video game, action game, action-adventure game, role-playing video game | — | Microsoft Windows |
| Elevator Action EX | 2D platform game, run and gun | Altron | Game Boy Color |
| Eliminator | — | Magenta Software | Microsoft Windows |
| Eliminator | — | Linel | ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Elite Commander | casual game, sports video game | — | Microsoft Windows |
| Elite Dangerous | — | Frontier Developments | Microsoft Windows, macOS, Xbox Series X and Series S |
| Elite Dangerous: Arena | — | Frontier Developments | Microsoft Windows |
| Elite Forces: WWII Normandy | first-person shooter | 3LV Games | Microsoft Windows |
| Elitserien 2001 | sports video game | Electronic Arts | Microsoft Windows |
| Elitserien 95 | sports video game | — | — |
| Elva the Eco Dragon | adventure video game | — | Microsoft Windows |
| Elven Legacy: Siege | strategy video game | — | Microsoft Windows |
| Elven Warrior | — | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Elves in Paradise: Elf Bowling 2 | sports video game | NStorm | Microsoft Windows |
| Elves vs Goblins Defender | casual game, strategy video game | Magnussoft | Microsoft Windows |
| Elvira: The Arcade Game | — | Flair Software | DOS, Atari ST, Commodore 64 |
| Emberglass | adventure video game, action game, action-adventure game | — | Microsoft Windows, macOS |
| Emberlight | — | — | Microsoft Windows, macOS, Linux |
| Emerald Lake | — | — | Microsoft Windows |
| Emergency Fire Response | simulation video game | Monte Cristo | Microsoft Windows |
| Emiko's Pledge 2 | adventure video game, action game, action-adventure game | Anamik Majumdar | Microsoft Windows, Linux |
| Emily Archer and the Curse of Tutankhamun | casual game, adventure video game | Mad Data | Microsoft Windows |
| Emily: Displaced | — | Bossa Studios | Microsoft Windows, macOS |
| Emperium | casual game, strategy video game, role-playing video game | — | Microsoft Windows |
| Empire: Total War - Elite Units of the East | — | — | Microsoft Windows, macOS, Linux |
| Empires Apart | — | DESTINYbit | Microsoft Windows |
| EmptyBottle | — | — | Microsoft Windows |
| Empyre: Lords of the Sea Gates | role-playing video game | — | Microsoft Windows |
| En decemberdröm | — | Upside Studios | Microsoft Windows, macOS |
| En Garde! | action game | Fireplace Games | Microsoft Windows |
| En riktig jul | point-and-click adventure | Upside Studios | Microsoft Windows, macOS |
| End of War 1945 | casual game, action game | — | Microsoft Windows |
| Ender Magnolia: Bloom in the Mist | Metroidvania, role-playing video game | Live Wire | Microsoft Windows, Xbox Series X and Series S |
| Endgame | — | — | — |
| Endlanders : First Encounter | action game, role-playing video game | — | Microsoft Windows, Linux |
| Endless Dead | action game, strategy video game | Ghost Machine | Microsoft Windows |
| Endless Dungeon | roguelite | Q18416053 | Microsoft Windows, Xbox Series X and Series S |
| Endless Ocean 2: Adventures of the Deep | simulation video game, adventure video game | Arika | Wii |
| Endless Space | space opera video game, science fiction video game | Q18416053 | Microsoft Windows, macOS |
| ENDRR | — | — | Microsoft Windows |
| Enemy Engaged: Apache vs Havoc | — | Razorworks | Microsoft Windows |
| Enemy Engaged: RAH-66 Comanche vs. KA-52 Hokum | — | Razorworks | Classic Mac OS, Microsoft Windows |
| Enemy Infestation | — | Micro Forté | Microsoft Windows |
| Energy Cycle | puzzle video game | Sometimes You | Microsoft Windows, macOS, Linux, Xbox Series X and Series S |
| Engine Evolution 2021 | casual game, simulation video game, action game, racing video game, massively multiplayer online game, sports video game | — | Microsoft Windows |
| England Exchange | — | — | Microsoft Windows, macOS, Linux |
| ENOH | action game | — | Microsoft Windows |
| Enoki | casual game, adventure video game, action game, action-adventure game | Dnovel | Microsoft Windows |
| Enter the Dominatrix | — | Q1458317 | Microsoft Windows, Linux |
| Entropy | casual game, adventure video game | — | Microsoft Windows, macOS |
| Entropy: Zero 2 | post-apocalyptic video game, first-person shooter | Breadmen | Microsoft Windows |
| Envy the Dead | simulation video game, strategy video game, role-playing video game | Oleg Kazakov | Microsoft Windows |
| Eon of the Green: Area Delta (Prologue) | adventure video game, role-playing video game | — | Microsoft Windows |
| Eos | — | — | Microsoft Windows |
| Epic Chef | — | Infinigon Games | Microsoft Windows, Xbox Series X and Series S |
| Epic Mickey: Power of Illusion | post-apocalyptic video game, crossover fiction, platform game | DreamRift | Nintendo 3DS |
| Epic Quest of the 4 Crystals | casual game, adventure video game, strategy video game, role-playing video game | — | Microsoft Windows |
| Epic Tower for Tireless Lovers | casual game, action game, strategy video game | — | Microsoft Windows |
| Epistory | typing software, action-adventure game | — | Microsoft Windows, macOS, Linux |
| Equestrian Showjumper | — | — | — |
| Equinox | adventure video game | Open Alpha | Microsoft Windows, macOS |
| Erde: Nezu to Ki no Shita de | visual novel | — | — |
| Ereban: Shadow Legacy | platform game, stealth game | — | Microsoft Windows, Xbox Series X and Series S |
| Erebe | — | — | Microsoft Windows |
| Ero Tennis | casual game, simulation video game, action game, sports video game | — | Microsoft Windows, macOS, Linux |
| Erotic Jigsaw Puzzle 3 | casual game | — | Microsoft Windows |
| Erzurum | post-apocalyptic video game | — | Microsoft Windows |
| Escape Academy | action-adventure game, puzzle video game | Coin Crew Games | Microsoft Windows, Xbox Series X and Series S |
| Escape From Hard Drive | simulation video game | Fewjix | Microsoft Windows |
| Escape from Nowhere | casual game, simulation video game, adventure video game, racing video game | — | Microsoft Windows |
| Escape from Pulsar 7 | — | — | ZX Spectrum, Atari 8-bit family, TRS-80 Model I, web browser, BBC Micro, Commodore 16 and Plus/4, Commodore 64 |
| Escape From Russia: Mobilization | simulation video game, adventure video game, action game, action-adventure game | — | Microsoft Windows, Linux |
| Escape from Singe's Castle | — | — | Classic Mac OS, DOS, ZX Spectrum, Amstrad CPC, Commodore 64 |
| Escape from Tatris | casual game | — | Microsoft Windows |
| Escape from the Cosmic Abyss | casual game, action game | — | Microsoft Windows, Linux |
| Escape From The Dragons | — | — | Microsoft Windows, macOS, Linux |
| Escape from the hospital | — | — | Microsoft Windows, macOS, Linux |
| Escape from the tomb tower | adventure video game | — | Microsoft Windows, Linux |
| Escape Lala 2 - Retro Point and Click Adventure | — | — | Microsoft Windows, macOS, Linux |
| Escape Memoirs: Mansion Heist | casual game, adventure video game | — | Microsoft Windows |
| Escape Simulator 2 | puzzle video game | Pine Studio | Microsoft Windows, macOS, Linux |
| Escape the Darkness | — | — | Microsoft Windows |
| Escape Velocity | — | — | Microsoft Windows, macOS |
| Escapeworld Dilemma | — | — | Microsoft Windows |
| Eshe's Wish Adventure | casual game, adventure video game | — | Microsoft Windows |
| Eskimo Eddie | — | Ocean Software | Microsoft Windows, ZX Spectrum, Commodore 64 |
| ESP Ra.De. | bullet hell | CAVE | arcade video game machine |
| ESPER | — | Coatsink | Microsoft Windows |
| ESports Legend | casual game, simulation video game, strategy video game | — | Microsoft Windows |
| Eternal Edge + | adventure video game, action game, action-adventure game, role-playing video game | — | Microsoft Windows |
| Eternal Magic | — | — | Microsoft Windows |
| Eternal Radiance | visual novel, role-playing video game | — | Microsoft Windows |
| Eternia: Pet Whisperer | visual novel | — | Microsoft Windows, macOS, Linux |
| Eternium | adventure video game, action game, action-adventure game, role-playing video game | — | Microsoft Windows |
| Etherlords | — | Nival | Microsoft Windows |
| Etrian Odyssey III | role-playing video game | Q780528 | Microsoft Windows, Nintendo DS |
| Eurofighter Typhoon | — | Digital Image Design | Microsoft Windows |
| Europa Universalis II | — | Development Studio | Classic Mac OS, Microsoft Windows, macOS |
| Europe Bus Driver | — | — | Microsoft Windows |
| European Champions | — | — | Atari ST |
| European Ship Simulator | — | — | Microsoft Windows, macOS |
| Eve: New Generation | — | — | — |
| Eve: The Fatal Attraction | — | — | Microsoft Windows |
| Even if TEMPEST | otome game | Voltage | Microsoft Windows |
| Evening Star | — | — | Microsoft Windows |
| Evening Vibes | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Evenings on a Farm near Dikanka | adventure video game | Step Creative Group | Microsoft Windows |
| Eventide 2: The Sorcerer's Mirror | hidden object game | The House of Fables | Microsoft Windows, macOS, Linux |
| Eventide 3: Legacy of Legends | hidden object game | The House of Fables | Microsoft Windows, macOS, Linux |
| Everreach: Project Eden | action game, role-playing video game | Elder Games | Microsoft Windows |
| Eversion | — | Zaratustra Productions | Microsoft Windows, macOS, Linux |
| Everslash | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Everspace: Encounters | roguelite, space combat simulation game | ROCKFISH Games | Microsoft Windows, macOS, Linux |
| Everybody 1-2-Switch! | party video game | Nintendo | — |
| Everybody's Golf | sports video game | Camelot Software Planning | — |
| Everybody's Golf 2 | sports video game | Clap Hanz | — |
| Everybody's Golf 4 | sports video game | Clap Hanz | — |
| Everybody's Gone to the Rapture | — | The Chinese Room | Microsoft Windows |
| Everyday Baseball VR | — | — | Microsoft Windows |
| Everyday Genius: SquareLogic | puzzle video game | — | Microsoft Windows |
| Everyone Sing | — | Gusto Games | PlayStation 3, Wii |
| Evil Islands: Curse of the Lost Soul | role-playing video game | Nival | Microsoft Windows |
| Evil Ritual - Horror Escape | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Eville | casual game, adventure video game, action game, action-adventure game, strategy video game, role-playing video game | VestGames | Microsoft Windows, Xbox Series X and Series S |
| Eviron's Chronicles | strategy video game, role-playing video game, massively multiplayer online game | — | Microsoft Windows |
| Evolo.Mine | casual game | — | Microsoft Windows |
| Evolution | — | — | Microsoft Windows |
| Evolution of a Mini World: Physics Wonderland | casual game, simulation video game, adventure video game, strategy video game, role-playing video game | William at Oxford | Microsoft Windows |
| EvoWorld.io | action game, .io game, massively multiplayer online game | — | web browser, Android |
| EXceed 3rd - Jade Penetrate Black Package | — | — | Microsoft Windows |
| Exception | horizontally scrolling shooter | — | — |
| Excitebike | racing video game | Nintendo Research & Development 1 | NEC PC-8800 series, Nintendo Entertainment System, arcade video game machine, Sharp X1, Wii U, Wii |
| ExciteBots: Trick Racing | stunt racing video game, racing video game | Monster Games | Wii |
| EXE: Mainframe | — | — | Microsoft Windows, Linux |
| Existensis | casual game, adventure video game | — | Microsoft Windows, macOS |
| Existential Kitty Cat RPG | casual game, adventure video game, action game, action-adventure game, role-playing video game | — | Microsoft Windows |
| EXIT 4 - Portal | — | — | Microsoft Windows |
| Exocraft | casual game, simulation video game, action game, strategy video game, role-playing video game, massively multiplayer online game | — | Microsoft Windows, macOS |
| Exodemic | roguelike | — | Microsoft Windows |
| Exodus from the Earth | — | Parallax Arts Studio | Microsoft Windows |
| Exorcised | casual game, strategy video game | — | Microsoft Windows |
| Expedition Zero | horror video game | Enigmatic Machines | Microsoft Windows |
| Expeditions: A MudRunner Game | simulation video game | Saber Interactive | Microsoft Windows, Xbox Series X and Series S |
| Expeditions: Conquistador | tactical role-playing game | Logic Artists | Microsoft Windows, macOS, Linux |
| Expel | action game | — | Microsoft Windows |
| Experience: Colorblindness | — | — | Microsoft Windows |
| Explora II | adventure video game | Infomedia | Atari ST |
| Explosive Candy World | adventure video game, action game, action-adventure game | Ratalaika Games | Microsoft Windows, Xbox Series X and Series S |
| Extractors | — | — | DOS |
| Extreme Ghostbusters | — | — | Game Boy Color |
| Extreme Speed | casual game, adventure video game, action game, action-adventure game, role-playing video game, racing video game | — | Microsoft Windows |
| Extreme Tag! | casual game, action game | — | Microsoft Windows, macOS, Linux |
| Extreme Truck Stunts | casual game, simulation video game, racing video game, sports video game | — | Microsoft Windows |
| Extricate | — | — | Microsoft Windows |
| EyeToy: AntiGrav | — | Harmonix Music Systems | — |
| EyeToy: Kinetic | — | London Studio | — |
| EyeToy: Play 3 | — | London Studio | — |