| Yacht Dice : Global League | casual game | — | Microsoft Windows |
| Yakuman | mahjong video game | Intelligent Systems | Game Boy |
| Yakuza 0: Director's Cut | action-adventure game | Ryu ga Gotoku Studio | Microsoft Windows, Xbox Series X and Series S |
| Yakuza 3 | action-adventure game | Q122741 | PlayStation 3, Microsoft Windows |
| Yakuza 4 | action-adventure game | Q122741 | PlayStation 3, Microsoft Windows |
| Yakuza: Like a Dragon | turn-based role-playing game, role-playing video game | Ryu ga Gotoku Studio | Microsoft Windows, Xbox Series X and Series S |
| Yarudora Series Vol. 3: Sampaguita | — | — | — |
| Yasai Ninja | — | Recotechnology S.L. | Microsoft Windows |
| Yawara! 2 | visual novel | — | TurboGrafx-16 |
| Ye Olde Toggle Block Game | — | — | HP 95LX |
| Yeah! You Want "Those Games," Right? So Here You Go! Now, Let's See You Clear Them! | parody video game, puzzle video game | Monkey Craft | Microsoft Windows |
| Yes, Your Grace: Snowfall | — | Brave At Night | Microsoft Windows, Xbox Series X and Series S |
| Yinyang | casual game, adventure video game | — | Microsoft Windows |
| Yoga Lesson VR | — | — | Microsoft Windows |
| Yohane the Parhelion: Blaze in the Deepblue | Metroidvania | Inti Creates | Microsoft Windows, Xbox Series X and Series S |
| Yohane the Parhelion: Numazu in the Mirage | roguelike deck-building game | BeXide | Microsoft Windows, Android |
| Yoimachi-hime: Taishō Inwai Kyūketsuki-tan | eroge, visual novel | — | Microsoft Windows |
| Yokai Hunter Shintaro | casual game, adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Yokai's Wish | casual game, adventure video game | — | Microsoft Windows |
| Yokozuna Monogatari | — | — | Super Nintendo Entertainment System |
| Yomi Domini | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| YONESAWARA HOSPITAL | adventure video game | — | Microsoft Windows |
| Yooka-Laylee | — | — | Microsoft Windows, macOS, Linux |
| Yoostar | — | Blitz Games Studios | PlayStation 3 |
| Yosaku | action game | SNK | arcade video game machine |
| Yoshi's Island DS | platform game | Artoon | Nintendo DS, Wii U |
| Yoshi's Island: Super Mario Advance 3 | — | — | Wii U |
| Yoshi's Safari | light-gun shooter | Nintendo Research & Development 1 | Super Nintendo Entertainment System |
| Yosuga no Sora | eroge, ecchi, visual novel, harem | — | Microsoft Windows |
| You Are Weak | — | — | Microsoft Windows |
| You Don't Know Jack Movies | casual game, strategy video game | Jackbox Games | Microsoft Windows |
| You First | adventure video game, visual novel | — | Android |
| You will die a lot buddy, trust me! | — | — | Microsoft Windows |
| You're in the Movies | — | Zoë Mode | — |
| You... and who else? | casual game, simulation video game, adventure video game, strategy video game, role-playing video game | Aldorlea Games | Microsoft Windows |
| Youkoso! Sukebe Elf no Mori e | eroge, visual novel | — | Microsoft Windows |
| Young Merlin | — | Westwood Studios | Super Nintendo Entertainment System |
| Young Souls | beat 'em up | 1P2P Studio | Microsoft Windows, Xbox Series X and Series S |
| Your Shape: Fitness Evolved 2012 | fitness video game | — | — |
| Your Shape: Fitness Evolved 2013 | — | — | Wii U |
| Yousei | visual novel | SakeVisual | Microsoft Windows, macOS, Linux |
| YRek Lost In Portals | adventure video game, action game, action-adventure game | — | Microsoft Windows |
| Yu-Gi-Oh! 5D's World Championship 2011: Over the Nexus | — | — | Nintendo DS |
| Yu-Gi-Oh! Capsule Monster Coliseum | — | Konami | — |
| Yu-Gi-Oh! Dark Duel Stories | card battle video game | — | Game Boy Color |
| Yu-Gi-Oh! Nightmare Troubadour | card battle video game | — | Nintendo DS |
| Yuki Onna | survival horror, stealth game | Chilla's Art | Microsoft Windows |
| Yukigatari | eroge, visual novel | — | Microsoft Windows |
| Yukiuta | — | — | Microsoft Windows |
| Yuletide Legends: Who Framed Santa Claus | hidden object game | Brave Giant | Microsoft Windows, macOS, Linux |
| Yum Yum Cookstar | cooking simulation video game | 1st Playable Productions | Microsoft Windows, Xbox Series X and Series S |
| YUME : Special Edition | — | — | Microsoft Windows |
| Yummy Girls | casual game, simulation video game, role-playing video game | — | Microsoft Windows |
| Yunohana | eroge, bishōjo game, visual novel | Pulltop | Microsoft Windows |
| Yuzi Lims: Puzzle | casual game | — | Microsoft Windows |
| Yūshi no Monshō: Deep Dungeon | — | — | Famicom Disk System, MSX |