| Pro Cycling Manager 2010 | sports video game | Cyanide | PlayStation Portable |
| Pro Rugby Manager 2 | — | — | Microsoft Windows |
| Project Milo | — | Lionhead Studios | — |
| Puzzle Bobble 2 | puzzle video game | Taito | Neo Geo, Classic Mac OS, Microsoft Windows, Nintendo 64 |
| Puzzle Series Vol. 2: Crossword | puzzle video game | — | Nintendo DS |
| Quiet Christmas (Demo) | — | Nostatic Software | Android |
| R.B.I. Baseball 17 | baseball video game | — | — |
| Race'n'Chase | — | — | Microsoft Windows, DOS |
| Ragnarok Online Prime | massively multiplayer online game | — | Microsoft Windows |
| Railway Life | — | — | Microsoft Windows |
| Railway Operation Simulator | — | — | Microsoft Windows |
| RealSports Basketball | basketball video game | — | Atari 2600 |
| Record of Lodoss War | high fantasy video game, role-playing video game | — | Super Nintendo Entertainment System |
| Record of Lodoss War: The War of Heroes | high fantasy video game, role-playing video game | — | — |
| Resident Evil: Mercenaries Vs. | third-person shooter | Capcom | — |
| RHEM 3: The Secret Library | adventure video game | — | Microsoft Windows, macOS |
| Ridge Racer Driftopia | racing video game | — | PlayStation 3, Microsoft Windows |
| Rio Run | — | — | web browser |
| Road Rage 3 | racing video game | — | — |
| Robot Ponkottsu 64: Nanatsu no Umi no Caramel | role-playing video game | Red Entertainment | Nintendo 64 |
| Rockman EXE Phantom of Network | tactical role-playing game, real-time tactics | — | mobile phone |
| RWBY: Grimm Eclipse | adventure video game, action game, action-adventure game | Rooster Teeth Games | Microsoft Windows, macOS |
| SBK-09: Superbike World Championship | racing video game | Milestone S.r.l. | PlayStation 3, Microsoft Windows |
| Scribblenauts Unmasked: A DC Comics Adventure | crossover fiction, emergent gameplay | 5th Cell | Microsoft Windows, Wii U |
| Seas of Blood | — | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Sega 3D Reprint Archives 3: Final Stage | — | — | Nintendo 3DS |
| Sen megami ZERO | eroge, role-playing video game | Eushully | Microsoft Windows |
| Sensible World of Soccer '96/'97 | association football video game, sports video game | — | DOS |
| Signet City | — | Jump Over the Age | Microsoft Windows |
| SimCity 2000: Scenarios Volume I: Great Disasters | city-building game | Maxis | Classic Mac OS, Microsoft Windows, DOS, NEC PC-9800 series |
| Simon Tatham's Portable Puzzle Collection | — | — | — |
| SingStar The Dome | — | — | — |
| Sky Surfer | — | Toka | — |
| SongPop | music video game | — | Android |
| Soul Hackers 2 | role-playing video game | Q780528 | Microsoft Windows, Xbox Series X and Series S |
| Sporting Triangles | — | — | ZX Spectrum, Amstrad CPC |
| Sprint 2 | racing video game | Kee Games | arcade video game machine |
| Spy Snatcher | — | — | ZX Spectrum, Amstrad CPC, Amstrad PCW |
| Stack Light Rifle | — | — | ZX Spectrum |
| Star Time | massively multiplayer online real-time strategy game | Elemental Games | web browser |
| Star Wraith IV: Reviction | space simulator | — | Microsoft Windows |
| Steins;??? | — | Chiyomaru Studio, Mages | — |
| Stellar Dawn | — | Jagex | Java platform |
| Steve Davis World Snooker | — | — | Atari ST |
| Subversion | — | Introversion Software | — |
| Sudden Strike: Resource War | real-time strategy | Fireglow Games | Microsoft Windows |
| Supply Line | — | — | web browser |
| Synduality: Echo of Ada | action role-playing game, science fiction video game, third-person shooter | — | Microsoft Windows, Xbox Series X and Series S |