| Taimanin Asagi: Battle Arena | eroge, gacha game | EXNOA | — |
| Taimanin Kurenai | eroge, visual novel | Lilith | — |
| Talisman | — | Nomad Games | Android |
| Tantei Opera Milky Holmes | detective fiction | — | PlayStation Portable |
| Territory War 3 | turn-based strategy video game | Shawn Tanner | — |
| The Coma 2: Vicious Sisters | adventure video game, survival horror | Devespresso Games | Microsoft Windows, macOS, Linux, Xbox Series X and Series S |
| The Even More Incredible Machine | — | — | Microsoft Windows, macOS, DOS |
| The Generation Test: Tomorrow and Forever | — | Fenn’s Gaming Dojo Co., Ltd. | Microsoft Windows, macOS |
| The Incredibles: When Danger Calls | action-adventure game | ImaginEngine | Microsoft Windows, macOS |
| The Indestructibles | — | Bullfrog Productions | — |
| The Last Night | — | — | Microsoft Windows, macOS, Linux |
| The Making of a Prophet | — | MDickie Limited | Microsoft Windows |
| The Scriptwelder Collection | — | Scriptwelder Studio | Microsoft Windows |
| This is Football | — | — | — |
| This is Football Management | — | — | PlayStation 3, PlayStation Portable, PlayStation Vita |
| This Is Pool | — | VooFoo Studios | Microsoft Windows |
| Thrill Kill | — | Midway Studios – Los Angeles | — |
| TimeSplitters 4 | — | Crytek UK | — |
| Titan A.E. | — | Blitz Games Studios | — |
| To Heart | eroge, bishōjo game, dating sim, visual novel, harem | — | Microsoft Windows, PlayStation Portable |
| Tokyo Xtreme Racer Advance | arcade, racing video game | — | — |
| Tom Clancy's The Division Heartland | third-person shooter | Red Storm Entertainment | Microsoft Windows, Xbox Series X and Series S |
| Toradora! Portable | visual novel | — | PlayStation Portable |
| Trauma Center: Second Opinion | simulation video game | Q780528 | Wii |
| Tribes Universe | first-person shooter | Hi-Rez Studios | Microsoft Windows |
| Tron RUN/r | endless runner game | Sanzaru Games | Microsoft Windows |
| Tyrannosaurus Tex | — | Slitherine Software UK Limited | Game Boy Color |
| Umineko: Golden Fantasia | fighting game | 07th Expansion | Microsoft Windows |
| Uphill: Sierra Nevada Fire Rescue | — | Uphill Games | web browser |
| Vampire: The Masquerade – Out for Blood | interactive fiction | Choice of Games | Microsoft Windows, macOS, Linux |
| Vampire: The Masquerade – Sins of the Sires | interactive fiction | Choice of Games | Microsoft Windows, macOS, Linux |
| VenusBlood -Desire- | eroge, simulation video game | — | Microsoft Windows |
| VenusBlood -Empire- | eroge, simulation video game | — | Microsoft Windows |
| Viper Phase 1 | vertically scrolling shooter | Seibu Kaihatsu | arcade video game machine |
| Virtual Pool: Tournament Edition | — | — | — |
| Viva Football | — | — | Microsoft Windows |
| Wangan Midnight: Maximum Tune 3 | racing video game | — | arcade video game machine |
| Wangan Midnight: Maximum Tune 5 | racing video game | — | arcade video game machine |
| Wangan Midnight: Maximum Tune 6 | racing video game | — | arcade video game machine |
| War Along the Mohawk | — | — | Microsoft Windows |
| Warhammer 40,000: Dark Heresy | role-playing video game | Q106805418 | Microsoft Windows, Xbox Series X and Series S |
| Wedding Dash | — | — | Microsoft Windows, macOS, Nintendo DS |
| White Album | eroge, drama anime and manga, visual novel, harem | Aquaplus, Leaf | Microsoft Windows |
| White Album 2: Shiawase no Mukougawa | bishōjo game, visual novel | — | PlayStation 3, PlayStation Vita |
| WHITE ALBUM: Memories like Falling Snow | dating sim, visual novel | Aquaplus | PlayStation 3, Microsoft Windows |
| Wicked | — | — | Commodore 64 |
| Winter Games | winter sports video game | Epyx | Apple IIGS, Famicom Disk System, DOS, Nintendo Entertainment System, Atari 2600, ZX Spectrum, Amstrad CPC, Atari ST, Atari 7800, MSX +1 |
| World Championship Snooker | — | — | Microsoft Windows |